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RE: Problem with HESSIAN

From: Brogren, Jacob <Jacob.Brogren>
Date: Mon, 29 Jun 2009 14:32:39 +0200

Hi Leonid,

I tried to change to ADVAN8/ADVAN9 and TOL=8. I get the same error =

By the way, Martin Brgstrand tiped me about (F+DEL)**2 instead of =
F**2+DEL since NONMEM might not like the concept of 0 raised to the =
power of 2. However, this didn't change the outcome.

Best Regards


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-----Original Message-----
From: Leonid Gibiansky [mailto:LGibiansky
Sent: 29 juni 2009 13:31
To: Brogren, Jacob
Cc: Nmusers (E-mail)
Subject: Re: [NMusers] Problem with HESSIAN

DEL part is not needed (unless you do log-transform; and even then,
there are better methods).
Try TOL=8 and/or ADVAN8 ADVAN9


Leonid Gibiansky, Ph.D.
President, QuantPharm LLC
e-mail: LGibiansky at
tel: (301) 767 5566

Brogren, Jacob wrote:
> Hi, thank's for the advice. Unfortunately neither "DEL=0.01" nor =
"S3=V3" resolved the issue. I've also tried log-transforming both =
sides with no improvement.
> Regards
> Jacob
Received on Mon Jun 29 2009 - 08:32:39 EDT

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