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RE: Problem with HESSIAN

From: Brogren, Jacob <Jacob.Brogren>
Date: Mon, 29 Jun 2009 16:49:38 +0200

Hi Leonid,

thank you for your input. I tried what you recommended. With FO NONMEM =
seems to enter a black hole: nothing gets out of the MONITORING OF =
SEARCH. I also removed ALAG but the problem is still there. Regarding =
ETAs, I have shuffled them around to see if it had an impact. But it =
didn't...

This is a bit frustrating so I am realy grateful for all suggestions I =
can get from nmusers.

Best Regards

Jacob


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-----Original Message-----
From: Leonid Gibiansky [mailto:LGibiansky
Sent: 29 juni 2009 14:51
To: Brogren, Jacob
Cc: Nmusers (E-mail)
Subject: Re: [NMusers] Problem with HESSIAN


Note also that your models are not identical: in ADVAN4 realization, you =

put random effect on ALAG1 while in ADVAN6 it is on F1.

Try to remove ALAG1 (or fix it at 0.0001 or some small value, before the =

first observation). The error could be related to ALAG1 difficulties.

Also, start ADVAN6 problem with the final values of ADVAN4 problem
(could be with MAXEVAL=0), just to get something converged. It could =
be
even FO: just to start with something. Then, after you see that the bulk =

part is correct, you can move on to sort out details.

Leonid

--------------------------------------
Leonid Gibiansky, Ph.D.
President, QuantPharm LLC
web: www.quantpharm.com
e-mail: LGibiansky at quantpharm.com
tel: (301) 767 5566




Brogren, Jacob wrote:
> Hi Leonid,
>
> I tried to change to ADVAN8/ADVAN9 and TOL=8. I get the same error =
message.
>
> By the way, Martin Brgstrand tiped me about (F+DEL)**2 instead of =
F**2+DEL since NONMEM might not like the concept of 0 raised to the =
power of 2. However, this didn't change the outcome.
>
> Best Regards
>
> Jacob
>
>
> =
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> Confidentiality Notice: This message is private and may contain =
confidential and proprietary information. If you have received this =
message in error, please notify us and remove it from your system and =
note that you must not copy, distribute or take any action in reliance =
on it. Any unauthorized use or disclosure of the contents of this =
message is not permitted and may be unlawful.
>
> -----Original Message-----
> From: Leonid Gibiansky [mailto:LGibiansky
> Sent: 29 juni 2009 13:31
> To: Brogren, Jacob
> Cc: Nmusers (E-mail)
> Subject: Re: [NMusers] Problem with HESSIAN
>
>
> Jacob,
> DEL part is not needed (unless you do log-transform; and even then,
> there are better methods).
> Try TOL=8 and/or ADVAN8 ADVAN9
>
> Leonid
>
> --------------------------------------
> Leonid Gibiansky, Ph.D.
> President, QuantPharm LLC
> web: www.quantpharm.com
> e-mail: LGibiansky at quantpharm.com
> tel: (301) 767 5566
>
>
>
>
> Brogren, Jacob wrote:
>> Hi, thank's for the advice. Unfortunately neither "DEL=0.01" nor =
"S3=V3" resolved the issue. I've also tried log-transforming both =
sides with no improvement.
>>
>> Regards
>>
>> Jacob
>>
>>
>
Received on Mon Jun 29 2009 - 10:49:38 EDT

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