NONMEM Users Network Archive

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RE: calculation of AUC

From: Bill Bachman <bachmanw>
Date: Fri, 20 Mar 2009 09:17:02 -0400

The easiest answer is to work it out. Do some simulations (without
variability) with multiple subjects with identical PK parameters BUT
different sampling times. Tabulate your AUCs and compare the results for
different sampling times!

 

  _____

From: owner-nmusers
Behalf Of Martin Bergstrand
Sent: Friday, March 20, 2009 8:45 AM
To: 'Ethan Wu'; nmusers
Subject: RE: [NMusers] calculation of AUC

 

Dear Ethan,

 

You need to provide more information on how you plan to calculate AUC
otherwise the question can't be answered. It is of course possible to
calculate the AUC without any influence of the sampling frequency. You
should be able to find examples of how to do this in the NMusers archive.
See for example the answer from Mats Karlsson in this thread
(http://nonmem.org/nonmem/nm/98apr032002.html).

 

Kind regards,

 

Martin Bergstrand, MSc, PhD student

-----------------------------------------------

Department of Pharmaceutical Biosciences,
Uppsala University

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P.O. Box 591

SE-751 24 Uppsala

Sweden

-----------------------------------------------

 <mailto:martin.bergstrand

-----------------------------------------------

Work: +46 18 471 4639

Mobile: +46 709 994 396

Fax: +46 18 471 4003

 

 

From: owner-nmusers
Behalf Of Ethan Wu
Sent: den 20 mars 2009 13:05
To: nmusers
Subject: [NMusers] calculation of AUC

 

Hi all, to calculate AUC of one of the compartments using ADVAN6, if it is a
fixed time interval, will the AUC be influenced by the frequncy of sampling
of the dataset within this interval or not?

thanks

 


  _____

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Received on Fri Mar 20 2009 - 09:17:02 EDT

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