NONMEM Users Network Archive

Hosted by Cognigen

Fw: calculation of AUC

From: Michael.J.Fossler
Date: Fri, 20 Mar 2009 09:42:59 -0400

I second Bill's suggestion to work this out on your own for your specific
problem. This forum can help you with general questions and overall
approaches, but very specific queries like this are for you and your
colleagues to hash out.


----- Forwarded by Michael J Fossler/PharmRD/GSK on 03/20/2009 09:40 AM
-----

"Bill Bachman" <bachmanw
Sent by: owner-nmusers
20-Mar-2009 09:17
 
To
"'Martin Bergstrand'" <martin.bergstrand
<ethan.wu75
cc

Subject
RE: [NMusers] calculation of AUC






The easiest answer is to work it out. Do some simulations (without
variability) with multiple subjects with identical PK parameters BUT
different sampling times. Tabulate your AUCs and compare the results for
different sampling times!
 

From: owner-nmusers
On Behalf Of Martin Bergstrand
Sent: Friday, March 20, 2009 8:45 AM
To: 'Ethan Wu'; nmusers
Subject: RE: [NMusers] calculation of AUC
 
Dear Ethan,
 
You need to provide more information on how you plan to calculate AUC
otherwise the question can?t be answered. It is of course possible to
calculate the AUC without any influence of the sampling frequency. You
should be able to find examples of how to do this in the NMusers archive.
See for example the answer from Mats Karlsson in this thread (
http://nonmem.org/nonmem/nm/98apr032002.html).
 
Kind regards,
 
Martin Bergstrand, MSc, PhD student
-----------------------------------------------
Department of Pharmaceutical Biosciences,
Uppsala University
-----------------------------------------------
P.O. Box 591
SE-751 24 Uppsala
Sweden
-----------------------------------------------
martin.bergstrand
-----------------------------------------------
Work: +46 18 471 4639
Mobile: +46 709 994 396
Fax: +46 18 471 4003
 
 
From: owner-nmusers
On Behalf Of Ethan Wu
Sent: den 20 mars 2009 13:05
To: nmusers
Subject: [NMusers] calculation of AUC
 
Hi all, to calculate AUC of one of the compartments using ADVAN6, if it is =

a fixed time interval, will the AUC be influenced by the frequncy of
sampling of the dataset within this interval or not?
thanks
 
No viruses found in this incoming message
Scanned by iolo AntiVirus 1.5.6.4
http://www.iolo.com

picture
(image/jpeg attachment: 01-part)

Received on Fri Mar 20 2009 - 09:42:59 EDT

The NONMEM Users Network is maintained by ICON plc. Requests to subscribe to the network should be sent to: nmusers-request@iconplc.com.

Once subscribed, you may contribute to the discussion by emailing: nmusers@globomaxnm.com.