NONMEM Users Network Archive

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single observation

From: Khaled Mohammed Abduljalil <kabdulja>
Date: Mon, 30 Mar 2009 17:59:44 +0200

Dear Nonmem-user,

I have a large sample size study, but only single
observation for a drug concentration and single
observation for its effect at steady state is available
per subject.

As many parameters had been fixed to prior information,
model mis-specification is the majer issue i met. So, On
which criteria should should I rely to evaluate the model,
specially the pharmacodynamic one? Any suggestion ?

many thanks
khaled
Received on Mon Mar 30 2009 - 11:59:44 EDT

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