NONMEM Users Network Archive

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RE: NM7 question

From: Bauer, Robert <Robert.Bauer>
Date: Wed, 4 Nov 2009 19:50:13 -0500


Robert J. Bauer, Ph.D.
Vice President, Pharmacometrics
ICON Development Solutions

Tel: (215) 616-6428
Mob: (925) 286-0769
Email: Robert.Bauer





From: owner-nmusers
On Behalf Of Sam Liao
Sent: Wednesday, November 04, 2009 7:31 PM
To: 'nmusers'
Subject: [NMusers] NM7 question

Dear NONMEM team:

To run the M3 method to handle BQL samples, we have to use
method=LAPLACIAN NUMERICAL SLOW in NM6. Can we use the new methods =
NM7 such as IMP, SAEM or BAYES if we have to run the M3 method?


Best regards,

Sam Liao

Pharmax Reseach


From: owner-nmusers
On Behalf Of Nick Holford
Sent: Wednesday, November 04, 2009 6:43 PM
To: nmusers
Subject: Re: [NMusers] advan8 vs. advan13 (CORRECTION)



Thanks to Peiming Ma and Thuy Vu for pointing out an error in my attempt
to transform bioavailability into its logit.

The logit transformation of a probability is ln(P/(1-P)) i.e. the log of
the odds ratio. The reverse transform is correct i.e. exp(logit) is the
odds ratio and P is then OR/(1+OR) (or 1/1+exp(-logit)).

If THETA(1) is the bioavailability then this is (I hope) the correct
transformation of THETA(1) and reverse transform to get the individual
bioavailability with a random effect constrained to be within 0 and 1.

MU_1=LOG(THETA(1)/(1-THETA(1)) ; logit of population bioavailability

EXPP=MU_1+ETA(1) ; add random effect

BIO=1/(1+EXP(-EXP(EXPP))) ; individual bioavailability


Nick Holford, Professor Clinical Pharmacology
Dept Pharmacology & Clinical Pharmacology
University of Auckland,85 Park Rd,Private Bag 92019,Auckland,New Zealand
tel:+64(9)923-6730 fax:+64(9)373-7090 mobile:+64(21)46 23 53
email: n.holford

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Received on Wed Nov 04 2009 - 19:50:13 EST

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