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Intensive course: 'Concepts and Applications of Predicting A DME, Pharmacokinetics and Population Variability' - Prince ton, NJ, USA

From: Masoud Jamei <masoud.jamei>
Date: Fri, 13 Nov 2009 13:47:45 -0000

 Simcyp, the leader in mechanistic in vitro - in vivo extrapolation (IVIVE)
of pharmacokinetics invites you to register for the well-established and

Intensive course: 'Concepts and Applications of Predicting ADME,
Pharmacokinetics and Population Variability'

17th - 21st May 2010

Princeton, New Jersey, USA

The course is comprised of lectures, delivered by leading experts in each
field of ADME, interspersed with interactive workshops centred around
practical examples demonstrating how in vitro data generated during drug
development can be used to predict:

* Metabolic drug clearance (CL)
* Metabolic drug-drug interactions (DDIs)
* Gut first-pass metabolism
* Oral drug absorption incorporating food effects and the impact of
dosage form
* Effect of transporters and enterohepatic recirculation on kinetics
* Drug distribution to different organs
* Population variability in drug concentration-time profiles
* Variation in kinetics in specific populations (paediatrics, ethnic
groups, various disease populations)
* Time-course of drug in plasma that fits observed clinical data
(achieved using fitting modules within physiologically-based
pharmacokinetics (PBPK) models combined with drug specific in vitro

The main emphasis is on using data generated in pre-clinical stages to
understand the kinetic behaviour of drugs in various target populations.
This informs decisions on the conduct and optimal design of clinical studies
with the ultimate aim of improving the quality of submissions for regulatory

The complete course runs from 17th - 21st May at the Nassau Inn, Princeton,
NJ. Delegates may also choose to register for part of the course:

Part I: 17th - 19th May 2010
Part II: 19th - 21st May 2010

For further information and registration details, please visit our website





Received on Fri Nov 13 2009 - 08:47:45 EST

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