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Intensive course: 'Concepts and Applications of Predicting ADME, Pharmacokinetics and Population Variability' - Princeton, NJ, USA

From: M Jamei <masoud.jamei>
Date: Tue, 17 Nov 2009 21:14:52 +0000

 Simcyp, the leader in mechanistic *in vitro* – *in vivo* extrapolation
(IVIVE) of pharmacokinetics invites you to register for the well-establishe=
d
and renowned:

*Intensive course: ‘Concepts and Applications of Predicting ADME,
Pharmacokinetics and Population Variability’ *

*17th – 21st May 2010*

*Princeton, New Jersey, USA*

The course is comprised of lectures, delivered by leading experts in each
field of ADME, interspersed with interactive workshops centred around
practical examples demonstrating how *in vitro *data generated during drug
development can be used to predict:

   - Metabolic drug clearance (CL)
   - Metabolic drug-drug interactions (DDIs)
   - Gut first-pass metabolism
   - Oral drug absorption incorporating food effects and the impact of
   dosage form
   - Effect of transporters and enterohepatic recirculation on kinetics
   - Drug distribution to different organs
   - Population variability in drug concentration-time profiles
   - Variation in kinetics in specific populations (paediatrics, ethnic
   groups, various disease populations)
   - Time-course of drug in plasma that fits observed clinical data
   (achieved using fitting modules within physiologically-based
   pharmacokinetics (PBPK) models combined with drug specific in
*vitro*information)

The main emphasis is on using data generated in pre-clinical stages to
understand the kinetic behaviour of drugs in various target populations.
This informs decisions on the conduct and optimal design of clinical studie=
s
with the ultimate aim of improving the quality of submissions for regulator=
y
approval.

The complete course runs from 17th – 21st May at the Nassau Inn, Princeto=
n,
NJ. Delegates may also choose to register for part of the course:

*Part I: *17th – 19th May 2010
*Part II: *19th – 21st May 2010

For further information and registration details, please visit our website
at:
http://www.simcyp.com/ProductServices/Workshops/20100517_New_Jersey.htm?p=
=1




Regards

Masoud

Received on Tue Nov 17 2009 - 16:14:52 EST

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