NONMEM Users Network Archive

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NMUSERS-modeling dose and response

From: Varsha Mehta <varsham>
Date: Wed, 25 Nov 2009 11:51:23 -0500

Dera NMUSERS:
I have a dataset where an anticoagulant has been administered and the =
response measured as unils/mL. Due to the inherent difficulty associated =
with measuring plasma concentrations of this drug no such measurements are =
available. I am interested in determining the population PK of this agent =
and connecting the dose size to response.

Should I be using a linked PK-PD model? Can I use the response values in =
u/mL instead of plasma concentrations? Which model in the NONMEM library =
should I start with ADVAN 5 or 6?

Thanks in advance!!

Varsha

Varsha Mehta, MS(CRDSA), Pharm.D., FCCP
Clinical Associate Professor
Pharmacy, Pediatrics and Communicable Diseases
Clinical Pharmacist Neonatal Critical Care
University of Michigan
(O) 734-936-8985
(F) 734-936-6946
varsham

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Received on Wed Nov 25 2009 - 11:51:23 EST

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