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10th Fisher/Shafer NONMEM/PLT Tools Workshop

From: Steven Shafer <steven.shafer>
Date: Thu, 1 Oct 2009 07:15:52 -0400

Dear Colleagues:


Our next NONMEM Workshop is now just one month away. The workshop is being
held in Basel, Switzerland, from Tuesday, November 3rd through November
10th, 2009. You can see the course description and registration details at
<> There are still seats
available for this course.


Many of you received a note from Dennis Fisher earlier this week announcing
that PLT Tools 2.3 is now available for download ( <> PLT Tools is a graphical interface for the NONMEM System.
Although the focus of the workshop is NONMEM, the more advanced diagnostics
(e.g., visual predictive check, log-likelihood profiling, bootstrap
analysis) are presented in the context of PLT Tools because it automates the
generation of these diagnostics.


The workshop will be based on NONMEM VI. With the imminent release of NONMEM
7 by Globomax, Dennis and I have worked hard to see that PLT Tools is
compatible with NONMEM 7. If you are using NONMEM 7, or intend to switch to
NONMEM 7, the version of PLT Tools that we will distribute with the workshop
should ease the transition.


Our NONMEM Workshops are now in their 5th year. Dennis and I have spent the
past two years developing PLT Tools. We introduced PLT Tools as the workshop
platform for the 9th Fisher/Shafer NONMEM course last month, giving
participants in that course access to bootstrap analysis, log-likelihood
profiling, and jackknife analysis, in addition to the outstanding diagnostic
graphics from PLT Tools. The latest version incorporates suggestions from
the attendees at the last NONMEM workshop, including time after dose
graphics and improved bootstrap handling and is compatible with NONMEM 7.


You can download the completely functional unlicensed version of PLT Tools
from Model validation is facilitated with automated
procedures for visual predictive checks, log likelihood profiling,
jack-knife analysis, and extensive bootstrap analysis for determination of
standard errors. PLT Tools also includes a robust library of control streams
and a control stream editor. CFR 11 Part 22 compliance is built into the
program, as is extensive run archiving and creation of audit trails. PLT
Tools also includes a comprehensive set of graphical and statistical
analyses facilitate model development and testing. A sample output can be
downloaded from


The licensed version of PLT Tools supports multiple simultaneous NONMEM
runs, which can substantially facilitate throughput on multicore computers.
A multiuser networked version of PLT Tools is also available. The multiuser
networked version can distribute NONMEM jobs across multiple networked


One of the joys of teaching this course is the considerable evolution in
course material every time the workshop is offered. Dennis and I continuous
update the course materials, based both on feedback from course participants
and our own exploration of novel pharmacometric problems. The feedback from
the 9th course indicated that PLT Tools was exceedingly well received, and
workshop participants appreciated their having access to these advanced and
powerful tools.


Dennis and I hope to see you next month in Basel!




Steven L. Shafer, MD

Professor of Anesthesiology, Columbia University

Adjunct Professor of Anesthesia, Stanford University

Adjunct Professor of Biopharmaceutical Sciences, UCSF

Editor-in-Chief, Anesthesia & Analgesia



Received on Thu Oct 01 2009 - 07:15:52 EDT

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