NONMEM Users Network Archive

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multiple problems in a control file

From: Tremblay, Pierre-Olivier <potremblay>
Date: Thu, 1 Oct 2009 22:20:06 -0400

Hi,

I'm trying to run multiple single-subject problems within a single
control file but there is something I'm not doing right because when I
include the $SUBROUTINE LIBRARY option, then NONMEM won't estimate the
model parameters. However if I omit that option, I can't run the second
problem. I pasted my test control file below .

$PROB RUN# 001
$INPUT C ID SUBJ AMT RATE EVID DAY DAT1=DROP TAD TIME DV MDV
$DATA TESTDATA.CSV RECS=ID IGNORE=C LAST20=50
$SUBROUTINES ADVAN2 TRANS1 SUBROUTINE=LIBRARY
$PK
K=THETA(1)
V=THETA(2)
KA=THETA(3)
S2=V
$ERROR
Y = F + F*ERR(1)
IPRED=F
$EST PRINT=5 MAX=9999 SIG=3
$THETA
(0,0.5,);[K]
(0,3000,);[V]
(0, 1.3);[KA]
$OMEGA
0.1 ;[P]
$PROB RUN# 002
$INPUT C ID SUBJ AMT RATE EVID DAY DAT1=DROP TAD TIME DV MDV
$DATA TESTDATA.CSV RECS=ID NOREWIND IGNORE=C LAST20=50
$PK
K=THETA(1)
V=THETA(2)
KA=THETA(3)
S2=V
$ERROR
Y = F + F*ERR(1)
IPRED=F
$EST PRINT=5 MAX=9999 SIG=3
$THETA
(0,0.5,);[K]
(0,3000,);[V]
(0, 1.3);[KA]
$OMEGA
0.1 ;[P]
I'd really appreciate if somenone could point me in the right direction
with this.

Tx :o)

Pierre-Olivier


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Received on Thu Oct 01 2009 - 22:20:06 EDT

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