From: Fidler,Matt,FORT WORTH,R&D <*Matt.Fidler*>

Date: Tue, 13 Oct 2009 11:44:20 -0500

Kehua,

Option 1 is definitely better. This states that there is a possibility =

that a population falls into ALPH1 or ALPH2. Within that same =

population there are two populations for BASE.

The other option states that each person in the has distinct parameters =

that four populations fall into: ALPH - Pop1, ALPH - Pop 2, Base -Pop 1, =

or Base -Pop2. Therefore, if you selected ALPH - pop1, you wouldn't =

have the parameter base. (You require this by having P1 - P4 to add up =

to be one - the total probability).

A third option you may consider is if you have reason to believe that =

the populations that have ALPH1 and Base1 are the same:

$PRED

IF (MIXNUM.EQ.2) THEN

ALPH =THETA(1)

ELSE

ALPH = THETA(2)

ENDIF

IF (MIXNUM.EQ.2) THEN

BASE=THETA(3)

ELSE

BASE=THETA(4)

END IF

$MIX

P(1) = THETA(5)

P(2) = 1-THETA(5)

NSPOP = 2

I haven't run anything like Option 1, and am unsure if NONMEM supports =

two separate populations for ALPH and BASE. Has anyone tried this?

Matt.

________________________________

From: owner-nmusers

On Behalf Of wu kehua

Sent: Tuesday, October 13, 2009 10:58 AM

To: nmusers

Subject: [NMusers] a question about the mixture distribution

Hi,

I am a new NONMEM user. I have a question about mixture distribution.

I have two parameters. How to apply mixture distribution on the both =

parameters? I should use the first one or the second one?

First,

$PRED

IF (MIXNUM.EQ.2) THEN

ALPH =THETA(1)

END IF

IF (MIXNUM.EQ.1) THEN

ALPH = THETA(2)

ENDIF

IF (MIXNUM.EQ.3) THEN

BASE=THETA(3)

ELSE

BASE=THETA(4)

END IF

$MIX

P(1) = THETA(5)

P(2) = 1-THETA(5)

P(3)=THETA(6)

P(4)=1-THETA6)

NSPOP = 4

Second,

IF (MIXNUM.EQ.1) THEN

ALPH =THETA(1)

BASE=THETA(3)

END IF

IF (MIXNUM.EQ.2) THEN

ALPH = THETA(1)

BASE=THETA(4)

ENDIF

IF (MIXNUM.EQ.3) THEN

ALPH = THETA(2)

BASE=THETA(3)

ELSE

ALPH = THETA(2)

BASE=THETA(4)

END IF

$MIX

P(1) = THETA(5)

P(2) = THETA(6)

P(3)=THETA(7)

P(4)=1-THETA(5)-THETA(6)-THETA(7)

NSPOP = 4

Thank you very much!

Best regards,

Kehua

This e-mail (including any attachments) is confidential and may be =

legally privileged. If you are not an intended recipient or an =

authorized representative of an intended recipient, you are prohibited =

from using, copying or distributing the information in this e-mail or =

its attachments. If you have received this e-mail in error, please =

notify the sender immediately by return e-mail and delete all copies of =

this message and any attachments.

Thank you.

Received on Tue Oct 13 2009 - 12:44:20 EDT

Date: Tue, 13 Oct 2009 11:44:20 -0500

Kehua,

Option 1 is definitely better. This states that there is a possibility =

that a population falls into ALPH1 or ALPH2. Within that same =

population there are two populations for BASE.

The other option states that each person in the has distinct parameters =

that four populations fall into: ALPH - Pop1, ALPH - Pop 2, Base -Pop 1, =

or Base -Pop2. Therefore, if you selected ALPH - pop1, you wouldn't =

have the parameter base. (You require this by having P1 - P4 to add up =

to be one - the total probability).

A third option you may consider is if you have reason to believe that =

the populations that have ALPH1 and Base1 are the same:

$PRED

IF (MIXNUM.EQ.2) THEN

ALPH =THETA(1)

ELSE

ALPH = THETA(2)

ENDIF

IF (MIXNUM.EQ.2) THEN

BASE=THETA(3)

ELSE

BASE=THETA(4)

END IF

$MIX

P(1) = THETA(5)

P(2) = 1-THETA(5)

NSPOP = 2

I haven't run anything like Option 1, and am unsure if NONMEM supports =

two separate populations for ALPH and BASE. Has anyone tried this?

Matt.

________________________________

From: owner-nmusers

On Behalf Of wu kehua

Sent: Tuesday, October 13, 2009 10:58 AM

To: nmusers

Subject: [NMusers] a question about the mixture distribution

Hi,

I am a new NONMEM user. I have a question about mixture distribution.

I have two parameters. How to apply mixture distribution on the both =

parameters? I should use the first one or the second one?

First,

$PRED

IF (MIXNUM.EQ.2) THEN

ALPH =THETA(1)

END IF

IF (MIXNUM.EQ.1) THEN

ALPH = THETA(2)

ENDIF

IF (MIXNUM.EQ.3) THEN

BASE=THETA(3)

ELSE

BASE=THETA(4)

END IF

$MIX

P(1) = THETA(5)

P(2) = 1-THETA(5)

P(3)=THETA(6)

P(4)=1-THETA6)

NSPOP = 4

Second,

IF (MIXNUM.EQ.1) THEN

ALPH =THETA(1)

BASE=THETA(3)

END IF

IF (MIXNUM.EQ.2) THEN

ALPH = THETA(1)

BASE=THETA(4)

ENDIF

IF (MIXNUM.EQ.3) THEN

ALPH = THETA(2)

BASE=THETA(3)

ELSE

ALPH = THETA(2)

BASE=THETA(4)

END IF

$MIX

P(1) = THETA(5)

P(2) = THETA(6)

P(3)=THETA(7)

P(4)=1-THETA(5)-THETA(6)-THETA(7)

NSPOP = 4

Thank you very much!

Best regards,

Kehua

This e-mail (including any attachments) is confidential and may be =

legally privileged. If you are not an intended recipient or an =

authorized representative of an intended recipient, you are prohibited =

from using, copying or distributing the information in this e-mail or =

its attachments. If you have received this e-mail in error, please =

notify the sender immediately by return e-mail and delete all copies of =

this message and any attachments.

Thank you.

Received on Tue Oct 13 2009 - 12:44:20 EDT