NONMEM Users Network Archive

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Re: The system cannot execute the specified program

From: nonmem
Date: Sat, 17 Oct 2009 12:54:10 +0000 (GMT)

Hello Everyone,

Thenk you for your help. It sounds about right. I have difficultie=
s with 32-bit server (4 processors, Total Physical Memory 3,327.30=
 MB, Available Physical Memory 2.68 GB, Total Virtual Memory 6.7=
3 GB, Available Virtual Memory 839.90 MB) and do not have problems w=
ith 64-bit laptop (4 processors, 8GB ram). It looks like the execut=
ion slows down a little when I use more than 3 processors, but othervi=
se evetrything is fine. I guess it is a good time to switch to 64-bit=
 computers. =


Thanks,
Pavel


----- Original Message -----
From: Nick Holford =

Date: Friday, October 16, 2009 11:55 pm
Subject: Re: [NMusers] The system cannot execute the specified p=
rogram
To: nmusers =


> For 32 bit Windows systems with 4GB of RAM then only 2GB of RAM =

> is =

> accessible to applications. The other 2 GB is taken by the =

> Windows =

> Kernel. It is possible to give more RAM to applications using =

> the =

> boot.ini /3GB switch but this is only effective if the =

> applications (eg. =

> NONMEM) are specifically enabled to take advantage of this:
> =

> "Executables that can use the 3-GB address space are required to =

> have =

> the bit IMAGE_FILE_LARGE_ADDRESS_AWARE set in their image =

> header. To set =

> this bit, you must use Microsoft Visual Studio Version 6.0 or =

> later and =

> the Editbin.exe utility, which has the ability to modify the =

> image =

> header (/LARGEADDRESSAWARE) flag."
> =

> http://www.microsoft.com/whdc/system/platform/server/PAE/PAEme=
m.mspx
> =

> It should be possible to run editbin after you have created a =

> NONMEM.exe =

> but before you run it. This might allow more NONMEM runs to work =

> on the =

> same machine. But I cannot find a clear statement that LAA is =

> helpful to =

> run several instances of an application or if it only helps for =

> one =

> instance.
> =

> http://bilbroblog.com/wow64/hidden-secrets-of-w0w64-ndash-large-=

> address-space/
> =

> My limited comparisons of NONMEM 6 and NONMEM 7 indicate that =

> NONMEM 7 =

> is usually slower and may take a lot more RAM. So unless you =

> really need =

> to use a NONMEM 7 feature you will get more work done using =

> NONMEM 6.
> =

> Nick
> =

> Leonid Gibiansky wrote:
> > > You may need to increase your RAM to 6GB to solve this probl=
em.
> >
> > but keep in mind that on a 32-bit Windows machine it makes no =

> sense to =

> > go beyond 4 GB (computer will not be able to work with it any wa=
y).
> > Leonid
> >
> > --------------------------------------
> > Leonid Gibiansky, Ph.D.
> > President, QuantPharm LLC
> > web: www.quantpharm.com
> > e-mail: LGibiansky at quantpharm.com
> > tel: (301) 767 5566
> >
> >
> >
> >
> > Sam Liao wrote:
> >> According to ICON, this is due to the size of the RAM on yo=
ur =

> PC. If =

> >> you have less than 3 GB of RAM and running the ‘big’ nm7 =
job, =

> it will =

> >> not allow you to run more than 2 jobs at once. You may need=
 =

> to =

> >> increase your RAM to 6GB to solve this problem.
> >>
> >> =

> >>
> >> Best regards,
> >>
> >> Sam Liao
> >>
> >> Pharmax Research
> >>
> >> =

> >>
> >> *From:* owner-nmusers

> >> [mailto:owner-nmusers
 =

> >> *nonmem
> >> *Sent:* Friday, October 16, 2009 2:02 PM
> >> *To:* nonmem
> >> *Cc:* nmusers
> >> *Subject:* [NMusers] The system cannot execute the spec=
ified =

> program>>
> >> =

> >>
> >> > Hello NONMEM Users,
> >> > We have a computer with 4 processors. When I try to run=
 more
> >> > than 3 NONMEM7 jobs, I am getting the following message=
:
> >> > Starting nonmem execution ...
> >> > The system cannot execute the specified program.
> >> > KP9022.OUT
> >> > newline
> >> > 1 file(s) copied.
> >> > Could Not Find H:\4\output
> >> >
> >> > The message is code and directory independent. It alway=
s
> >> > appears when I try to run more than 3 codes. When I tes=
t
> >> > nonmem7 using a laptop, which also has 4 processors, =
I can
> >> > execute 4 programs. Also, when I had NONMEM6, I did=
 not have
> >> > this problem on the same machine.
> >> > Do you familiar with this problem? Thanks.
> >> > Pavel
> >> >
> >>
> =

> -- =

> Nick Holford, Professor Clinical Pharmacology
> Dept Pharmacology & Clinical Pharmacology
> University of Auckland, 85 Park Rd, Private Bag 92019, Aucklan=
d, =

> New Zealand
> n.holford
3-7090
> mobile: +64 21 46 23 53
> http://www.fmhs.auckland.ac.nz/sms/pharmacology/holford
> =

>

Received on Sat Oct 17 2009 - 08:54:10 EDT

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