NONMEM Users Network Archive

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Re: The system cannot execute the specified program

From: Nick Holford <n.holford>
Date: Sun, 18 Oct 2009 17:03:49 +1300

Juergen,

I'd be interested to know of your experience of how much estimation time
you save by making project specific installations. Given that you must
take additional time to setup SIZES and recompile NONMEM for each
project (say 10-15 minutes) how much time do you save per run compared
with having regular and big installations of NONMEM?

Nick

Jurgen Bulitta wrote:
>
> Dear Tom,
>
> Dear All,
>
>
>
> For those of us who prefer project specific NONMEM installations to
> save estimation time,
>
> it might be helpful, if ICON can provide some rough guidance on the
> main contributor
>
> to the RAM needs of NONMEM 7.
>
> I.e. is it primarily the number of observations, compartments, thetas,
> omegas, or
>
> another variable or some function of these variables?
>
>
>
> The following might be very cumbersome: Would it be possible to
> include a switch
>
> during the installation which disables certain NONMEM 7 features to
> save RAM.
>
> (I recognize that this might cause a lot of unpredictable software
> issues.)
>
> Dual CPU servers currently have around 8-18 RAM slots. 2 and 4 GB RAM
> chips are
>
> reasonably priced. Thus, on the 64-bit server side, this is probably a
> minor issue.
>
>
>
> Best wishes
>
> Juergen
>
>
>
>
>
>
>
>
>
> *From:* owner-nmusers
> [mailto:owner-nmusers
> *Sent:* Friday, October 16, 2009 3:14 PM
> *To:* nonmem
> *Cc:* nmusers
> *Subject:* RE: [NMusers] The system cannot execute the specified program
>
>
>
> Pavel,
>
>
>
> The message you describe is usually the result of not having enough
> memory available for the NONMEM 7 memory image. If you are using the
> "big" version of SIZES you may need about 1.6-2 GB of available memory
> for each job. For the efficient use of NONMEM 7's new methods more
> variables are now stored in memory than was the case for NONMEM VI.
> The memory image is larger even if one is not using the new methods.
>
> When using NONMEM 7 and the "reg" SIZES, I have been able to run 8
> jobs simultaneously on a dual processor dual core machine, but only
> 3-4 jobs when using the "big" version of SIZES depending upon what
> else is running. I have 3 GB of memory and the task manager indicates
> a maximum of about 7.4 GB via paging.
>
>
>
> Tom
>
> *Thomas M. Ludden Ph.D**.**
> *Vice-President, *Pharmacometrics* R&D*
> *ICON Development Solutions**
>
> *Tel:* + 1 410 696 3040
> *Mob: + **1 *410 258 2411
> *Fax: + 1 *410 480 0776
> *Email: thomas.ludden
>
> *Web:* www.icondevsolutions.com
>
> Image removed by sender.
>
>
>
> ------------------------------------------------------------------------
>
> *From:* owner-nmusers
> [mailto:owner-nmusers
> *Sent:* Friday, October 16, 2009 2:02 PM
> *To:* nonmem
> *Cc:* nmusers
> *Subject:* [NMusers] The system cannot execute the specified program
>
> > Hello NONMEM Users,
> > We have a computer with 4 processors. When I try to run more
> > than 3 NONMEM7 jobs, I am getting the following message:
> > Starting nonmem execution ...
> > The system cannot execute the specified program.
> > KP9022.OUT
> > newline
> > 1 file(s) copied.
> > Could Not Find H:\4\output
> >
> > The message is code and directory independent. It always
> > appears when I try to run more than 3 codes. When I test
> > nonmem7 using a laptop, which also has 4 processors, I can
> > execute 4 programs. Also, when I had NONMEM6, I did not have
> > this problem on the same machine.
> > Do you familiar with this problem? Thanks.
> > Pavel
> >
>
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--
Nick Holford, Professor Clinical Pharmacology
Dept Pharmacology & Clinical Pharmacology
University of Auckland, 85 Park Rd, Private Bag 92019, Auckland, New Zealand
n.holford
mobile: +64 21 46 23 53
http://www.fmhs.auckland.ac.nz/sms/pharmacology/holford


Received on Sun Oct 18 2009 - 00:03:49 EDT

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