NONMEM Users Network Archive

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RE: The system cannot execute the specified program

From: Ludden, Thomas <Thomas.Ludden>
Date: Mon, 19 Oct 2009 14:09:24 -0400

Based on limited experience with the sizing of variables in SIZES for
NONMEM 7.1.0, some known determinants of memory usage are the maximum
number of observations per individual, NO, the maximum number of
individuals, MAXIDS, and the maximum number of estimated parameters,
LPAR. The dimensions of many arrays are determined by these values.
There are likely to be other important determinants as well.
 
For the "reg" version of SIZES:
NO: 250
MAXIDS: 10000
LPAR: 70
 
For the "big" version:
NO: 500
MAXIDS: 15000
LPAR: 195
 
We will do a more systematic investigation of this issue and will report
the results when they are available.
 
Bob Bauer is working with Nous Infosystems to explore the practicality
of allocating memory for selected variables at the beginning of a
problem based on the specific needs of the problem. A future version
may incorporate this capability.
 
Tom

Thomas M. Ludden Ph.D.
Vice-President, Pharmacometrics R&D
ICON Development Solutions

Tel: + 1 410 696 3040
Mob: + 1 410 258 2411
Fax: + 1 410 480 0776
Email: thomas.ludden

Web: www.icondevsolutions.com

 <http://emailsignature/stationary/Icon_Development_Solutions.gif>

 

 

 

________________________________

From: Jurgen Bulitta [mailto:jbulitta
Sent: Saturday, October 17, 2009 10:59 PM
To: Ludden, Thomas; nonmem
Cc: nmusers
Subject: RE: [NMusers] The system cannot execute the specified program



Dear Tom,

Dear All,

 

For those of us who prefer project specific NONMEM installations to save
estimation time,

it might be helpful, if ICON can provide some rough guidance on the main
contributor

to the RAM needs of NONMEM 7.

I.e. is it primarily the number of observations, compartments, thetas,
omegas, or

another variable or some function of these variables?

 

The following might be very cumbersome: Would it be possible to include
a switch

during the installation which disables certain NONMEM 7 features to save
RAM.

(I recognize that this might cause a lot of unpredictable software
issues.)

Dual CPU servers currently have around 8-18 RAM slots. 2 and 4 GB RAM
chips are

reasonably priced. Thus, on the 64-bit server side, this is probably a
minor issue.

 

Best wishes

Juergen

 

 

 

 

From: owner-nmusers
On Behalf Of Ludden, Thomas
Sent: Friday, October 16, 2009 3:14 PM
To: nonmem
Cc: nmusers
Subject: RE: [NMusers] The system cannot execute the specified program

 

Pavel,

 

The message you describe is usually the result of not having enough
memory available for the NONMEM 7 memory image. If you are using the
"big" version of SIZES you may need about 1.6-2 GB of available memory
for each job. For the efficient use of NONMEM 7's new methods more
variables are now stored in memory than was the case for NONMEM VI. The
memory image is larger even if one is not using the new methods.

When using NONMEM 7 and the "reg" SIZES, I have been able to run 8 jobs
simultaneously on a dual processor dual core machine, but only 3-4 jobs
when using the "big" version of SIZES depending upon what else is
running. I have 3 GB of memory and the task manager indicates a maximum
of about 7.4 GB via paging.

 

Tom

Thomas M. Ludden Ph.D.
Vice-President, Pharmacometrics R&D
ICON Development Solutions

Tel: + 1 410 696 3040
Mob: + 1 410 258 2411
Fax: + 1 410 480 0776
Email: thomas.ludden

Web: www.icondevsolutions.com

 

 

________________________________

From: owner-nmusers
On Behalf Of nonmem
Sent: Friday, October 16, 2009 2:02 PM
To: nonmem
Cc: nmusers
Subject: [NMusers] The system cannot execute the specified program

> Hello NONMEM Users,
> We have a computer with 4 processors. When I try to run more
> than 3 NONMEM7 jobs, I am getting the following message:
> Starting nonmem execution ...
> The system cannot execute the specified program.
> KP9022.OUT
> newline
> 1 file(s) copied.
> Could Not Find H:\4\output
>
> The message is code and directory independent. It always
> appears when I try to run more than 3 codes. When I test
> nonmem7 using a laptop, which also has 4 processors, I can
> execute 4 programs. Also, when I had NONMEM6, I did not have
> this problem on the same machine.
> Do you familiar with this problem? Thanks.
> Pavel
>

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Received on Mon Oct 19 2009 - 14:09:24 EDT

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