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RE: method=ITS, OPTIMIZATION NOT TESTED (?!)

From: Bauer, Robert <Robert.Bauer>
Date: Sun, 25 Oct 2009 23:29:28 -0400

Pavel:
The objective function progress looks good. You should expect some
Monte Carlo fluctuations. You should also run more iterations (perhaps
NITER=200), and set CTYPE=3, which turns on the termination tester. =
To
resume where you left off, rename your new control stream file, and put
in the following lines.
 
$EST METHOD=CHAIN NSAMPLE=0 ISAMPLE=50
FILE=my_old_control_stream_file.ext
$EST METHOD=IMP NITER=200 CTYPE=3 =
FILE=my_new_control_stream_file.ext
 
Make sure you are linear MU referencing to get the greatest efficiency.
 
 

Robert J. Bauer, Ph.D.
Vice President, Pharmacometrics
ICON Development Solutions

Tel: (215) 616-6428
Mob: (925) 286-0769
Email: Robert.Bauer
Web: www.icondevsolutions.com

 

 

 


________________________________

From: owner-nmusers
On Behalf Of nonmem
Sent: Saturday, October 24, 2009 8:03 PM
To: nmusers
Subject: [NMusers] method=ITS, OPTIMIZATION NOT TESTED (?!)



Hello NONMEM Team,

I found method=imp useful when there are local maxima. Nevertheless, =
at
the end of optimization it prints a message, which makes me feel
somewhat uncomfortable: OPTIMIZATION NOT TESTED. Also, the final
objective function is not always the lowest one. An example is below.
How do we interpret the results in this case?

 THETAS THAT ARE SIGMA-LIKE:
 MONITORING OF SEARCH:

 iteration 0 OBJ= 10625.663135214874
 iteration 1 OBJ= 10601.188754983375
 iteration 2 OBJ= 10537.895114114934
 iteration 3 OBJ= 10471.674625518765
 iteration 4 OBJ= 10430.297437731866
 iteration 5 OBJ= 10461.973668565577
 iteration 6 OBJ= 10462.638834406265
 iteration 7 OBJ= 10423.464983371641
 iteration 8 OBJ= 10417.959956991735
 iteration 9 OBJ= 10417.594007447198
 iteration 10 OBJ= 10414.708468642830
 iteration 11 OBJ= 10427.810693855947
 iteration 12 OBJ= 10412.889081059604
 iteration 13 OBJ= 10411.980622268416
 iteration 14 OBJ= 10424.501127174915
 iteration 15 OBJ= 10416.332869468861
 iteration 16 OBJ= 10416.622580251338
 iteration 17 OBJ= 10412.401585537709
 iteration 18 OBJ= 10415.117257355550
 iteration 19 OBJ= 10415.302370961055
 iteration 20 OBJ= 10409.066188189252
 iteration 21 OBJ= 10413.780620468329
 iteration 22 OBJ= 10410.787496174480
 iteration 23 OBJ= 10410.633582415931
 iteration 24 OBJ= 10409.970257443048
 iteration 25 OBJ= 10409.702420124611
 iteration 26 OBJ= 10409.213115058612
 iteration 27 OBJ= 10409.690639357370
 iteration 28 OBJ= 10410.016047785200
 iteration 29 OBJ= 10408.157468814226
 iteration 30 OBJ= 10407.779614704938
 iteration 31 OBJ= 10410.164563157052
 iteration 32 OBJ= 10408.364552302961
 iteration 33 OBJ= 10407.431920727997
 iteration 34 OBJ= 10408.286189641487
 iteration 35 OBJ= 10407.907347050501
 iteration 36 OBJ= 10407.451608770069
 iteration 37 OBJ= 10407.189482360372
 iteration 38 OBJ= 10406.484357336147
 iteration 39 OBJ= 10409.167125968375
 iteration 40 OBJ= 10406.840873883246
 iteration 41 OBJ= 10407.679485561714
 iteration 42 OBJ= 10405.341101045238
 iteration 43 OBJ= 10404.704382334516
 iteration 44 OBJ= 10405.348023082915
 iteration 45 OBJ= 10405.347406984720
 iteration 46 OBJ= 10401.873473651774
 iteration 47 OBJ= 10404.036204419035
 iteration 48 OBJ= 10405.072916975221
 iteration 49 OBJ= 10402.976628923887
 Elapsed estimation time in seconds: 30420.73
 iteration 50 OBJ= 10403.285958168881

 #TERM:
 OPTIMIZATION NOT TESTED

Thanks,

Pavel

 

 

 

 


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Received on Sun Oct 25 2009 - 23:29:28 EDT

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