NONMEM Users Network Archive

Hosted by Cognigen


From: Simbarashe Peter Zvada <simba.zvada>
Date: Thu, 10 Sep 2009 16:25:40 +0200

Dear Lata

If I understand correctly that you are not referring to single dose
per occasion/period, compound PK can be affected by its physiological
For example, a compound can induce its own clearance / elimination
(autoinduction) after a couple of consecutive doses.
This is particularly the case with rifamycins best exemplified by
rifampicin. Carbamazepine does the same thing.
It most cases, it takes two or more weeks for the inductive effects to
disappear. So you also need to check the washout period.
Hope this answers your question?

Hope this answers your question?

University of Cape Town
Pharmacometrics Unit

On Thu, Sep 10, 2009 at 3:29 PM, Maganti, Lata <lata_maganti
> Hi all
> Are there any compounds or compound classes where the drug administered
> in one period may produce a physiological effect which would affect the
> PK of the drug administered in the next period, even if there is no PK
> present at predose in the next period.
> Thanks
> Lata
> Notice:  This e-mail message, together with any attachments, contains
> information of Merck & Co., Inc. (One Merck Drive, Whitehouse Station,
> New Jersey, USA 08889), and/or its affiliates (which may be known
> outside the United States as Merck Frosst, Merck Sharp & Dohme or
> MSD and in Japan, as Banyu - direct contact information for affiliates is
> available at that may be
> confidential, proprietary copyrighted and/or legally privileged. It is
> intended solely for the use of the individual or entity named on this
> message. If you are not the intended recipient, and have received this
> message in error, please notify us immediately by reply e-mail and
> then delete it from your system.
Received on Thu Sep 10 2009 - 10:25:40 EDT

The NONMEM Users Network is maintained by ICON plc. Requests to subscribe to the network should be sent to:

Once subscribed, you may contribute to the discussion by emailing: