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Re:

From: Simbarashe Peter Zvada <simba.zvada>
Date: Thu, 10 Sep 2009 16:25:40 +0200

Dear Lata

If I understand correctly that you are not referring to single dose
per occasion/period, compound PK can be affected by its physiological
effects.
For example, a compound can induce its own clearance / elimination
(autoinduction) after a couple of consecutive doses.
This is particularly the case with rifamycins best exemplified by
rifampicin. Carbamazepine does the same thing.
It most cases, it takes two or more weeks for the inductive effects to
disappear. So you also need to check the washout period.
Hope this answers your question?

Hope this answers your question?

---------------------
Simba
University of Cape Town
Pharmacometrics Unit

On Thu, Sep 10, 2009 at 3:29 PM, Maganti, Lata <lata_maganti
te:
>
> Hi all
> Are there any compounds or compound classes where the drug administered
> in one period may produce a physiological effect which would affect the
> PK of the drug administered in the next period, even if there is no PK
> present at predose in the next period.
> Thanks
> Lata
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Received on Thu Sep 10 2009 - 10:25:40 EDT

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