NONMEM Users Network Archive

Hosted by Cognigen

researcher in PBPK modelling

From: Mats Karlsson <mats.karlsson>
Date: Mon, 28 Sep 2009 21:25:23 +0200

Uppsala University hereby declares the following position to be open for

Researcher in Pharmacokinetic modelling

at the Department of Pharmacy, 2009-10-01 t o m 2010-09-31.

The research group: The PhD project will be performed in Professor Per
Artursson's research group (Drug Delivery). The Drug delivery group is
comprised of about 10 researchers of which half are PhD's, performs research
of highest international standard and is among the most cited in the world
in the fields of pharmacy and pharmacology. The research is founded on in
vitro studies of ADMET (absorption, distribution, metabolism, elimination,
toxicity) properties of drugs.

The position is supported by the drug company Roche through the Roche
Fellowship Program. The work will be performed in close collaboration with
researchers at Roche. Expertise in physiologically based pharmacokinetic
modeling (PBPK) and structure-property relationships will contribute to the
project. In our research group, we are currently developing models based on
differential equations for advanced analysis of cellular pharmacokinetics.
The initial position is for one year but may be extended for another two
years after completion of the goals for the first year.

The project: The overall goal of the project is to develop transparent in
silico models for how structural changes in drug molecules influence
pharmacokinetic ADMET-properties. The models will be linked to existing
PBPK-models in close collaboration with researchers at Roche. The main
motive for developing this software is to expand the use of in silico
simulations for structure effect relationships (SER) also to chemist for the
purpose of i) predict PK data from the molecular structures of new drug
candidates, and ii) investigate the impact of structural modifications on
such data. Thus, so-called "what-if"-functionalities should be built into
the software.

Qualifications: The eligible applicant should have a PhD degree or have a
corresponding degree. A well developed interest for working in a
multidisciplinary environment is an advantage, since the research project
will include programming, modeling and experiments. Your educational
background should include several of the following competencies:
mathematics, statistical analysis, medicinal chemistry, pharmacokinetics,
chemistry/biochemistry, cell biology and analytical chemistry. A genuine
interest in programming is important and experience from or focus on
modeling during the PhD/post doc studies is an advantage. A PhD in PK
modeling is an excellent background for this project but not a prerequisite.
Presently, we use Matlab for software development but you should preferably
have experience and/or knowledge about other computer languages as well,
such as C++, Java, and web programming.

The project is based on collaborations between different disciplines.
Excellent social skills, flexibility and ability for seamless collaborations
as well as independent work are required. The researcher is expected to
perform high quality research, to publish the results, and to contribute to
the initiation and development of research collaborations within the
research field. He/she is also expected to contribute to related research
projects within the research group, to participate actively in seminars and
research discussions, take own initiatives and to contribute to the future
development of the research program in the research group.

The Salary will be according to competence. Salary claim should be included
in the application.

Further information can be obtained from professor Per Artursson, tel
070-425 08 88 or via email: per.artursson

The application, which should contain a brief description of the research
experiences of the applicant, a complete CV, preferred starting date and
names and addresses (including email addresses) to three reference persons,
should be sent to Uppsala universitet, Registrator, UFV-PA 2009/2111, Box
256, SE-751 05 Uppsala, fax +46 18 471 20 00, no later than 5 October, 2009.
Letter of recommendation can be enclosed. If the application is sent by fax,
original material should be filed within a week after application deadline.



Mats Karlsson, PhD

Professor of Pharmacometrics

Dept of Pharmaceutical Biosciences

Uppsala University

Box 591

751 24 Uppsala Sweden

phone: +46 18 4714105

fax: +46 18 471 4003


Received on Mon Sep 28 2009 - 15:25:23 EDT

The NONMEM Users Network is maintained by ICON plc. Requests to subscribe to the network should be sent to:

Once subscribed, you may contribute to the discussion by emailing: