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Generating Cmax at end of infusion

From: Paul Hutson <prhutson>
Date: Tue, 06 Apr 2010 11:11:31 -0500
G'day.
I would like to generate a concentration at the end of an infusion of duration DUR.
I am using ADVAN3  TRANS4 with log transformed data.  Here is what I have tried, but I am getting an error that the parameter 'T' that I understood to be the machine time is undefined.  Can anyone suggest a proper way to give set Cmax=exp(Y) at the end of the infusion of length DUR?
Many thanks in advance.
Paul
$PK
...
TT=TIME

$ERROR
;I've also tried
;TT=TIME
;TT=T
IPRE=F
EDV=EXP(DV)
W=1
IF(F.GT.0) W=F
IRES=F-EDV
IWRE=IRES/W
LOGF=LOG(0.0001)
IF (F.GT.0) LOGF=LOG(F)
Y=LOGF+EPS(1)
;GENERATE CMAX AT END OF INFUSION (DUR)
 IF(DUR.EQ.TT) CMAX=EXP(Y)
--
Paul R

Paul R. Hutson, Pharm.D.

Associate Professor

UW School of Pharmacy

777 Highland Avenue

Madison WI 53705-2222

Tel  608.263.2496

Fax 608.265.5421

Pager 608.265.7000, p7856

Received on Tue Apr 06 2010 - 12:11:31 EDT

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