# RE: Generating Cmax at end of infusion

From: Denney, William S. <william_denney>
Date: Tue, 6 Apr 2010 13:21:32 -0400

Hi Paul,

If you have a row in your data file at TIME == DUR, then something like
the following should work (you would need to have DUR on each row for
this; there are other ways to do it that you don't have to have DUR on
each row):

\$ERROR
CMAX = 0
IPRE=F
EDV=EXP(DV)
W=1
IF(F.GT.0) W=F
IRES=F-EDV
IWRE=IRES/W
LOGF=LOG(0.0001)
IF (F.GT.0) LOGF=LOG(F)
Y=LOGF+EPS(1)
;GENERATE CMAX AT END OF INFUSION (DUR)
IF(DUR.EQ.TIME) CMAX=EXP(Y)

Thanks,

Bill

________________________________

From: owner-nmusers
On Behalf Of Paul Hutson
Sent: Tuesday, April 06, 2010 12:12 PM
To: NMUSERS
Subject: [NMusers] Generating Cmax at end of infusion

G'day.
I would like to generate a concentration at the end of an infusion of
duration DUR.
I am using ADVAN3 TRANS4 with log transformed data. Here is what I
have tried, but I am getting an error that the parameter 'T' that I
understood to be the machine time is undefined. Can anyone suggest a
proper way to give set Cmax=exp(Y) at the end of the infusion of length
DUR?
Paul
\$PK
...
TT=TIME

\$ERROR
;I've also tried
;TT=TIME
;TT=T
IPRE=F
EDV=EXP(DV)
W=1
IF(F.GT.0) W=F
IRES=F-EDV
IWRE=IRES/W
LOGF=LOG(0.0001)
IF (F.GT.0) LOGF=LOG(F)
Y=LOGF+EPS(1)
;GENERATE CMAX AT END OF INFUSION (DUR)
IF(DUR.EQ.TT) CMAX=EXP(Y)

--

Paul R. Hutson, Pharm.D.

Associate Professor

UW School of Pharmacy

777 Highland Avenue

Tel 608.263.2496

Fax 608.265.5421

Pager 608.265.7000, p7856

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