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RE: Generating Cmax at end of infusion

From: Eleveld, DJ <d.j.eleveld>
Date: Tue, 6 Apr 2010 20:22:28 +0200

Hi,

As others have suggested making an additional record at the known desired time is probably the most straightforward manner to get what you want. So this should probably be a preferred solution.

If you for some reason you cant to add a record (maybe you dont know the time beforehand), I think you can achieve what you want using MTIME(). This has the added advantage of working without going the $DES route and the associated slower run-times. I'll see if I can get something like that to work tomorrow, just as an excercise.

Can the experts give an opinion as to whether MTIME() should work or not?

Regards,

Douglas Eleveld


-----Original Message-----
From: owner-nmusers
Sent: Tue 4/6/2010 6:11 PM
To: NMUSERS
Subject: [NMusers] Generating Cmax at end of infusion
 
G'day.
I would like to generate a concentration at the end of an infusion of duration DUR.
I am using ADVAN3 TRANS4 with log transformed data. Here is what I have tried, but I am getting an error that the parameter 'T' that I understood to be the machine time is undefined. Can anyone suggest a proper way to give set Cmax=exp(Y) at the end of the infusion of length DUR?
Many thanks in advance.
Paul
$PK
...
TT=TIME

$ERROR
;I've also tried
;TT=TIME
;TT=T
IPRE=F
EDV=EXP(DV)
W=1
IF(F.GT.0) W=F
IRES=F-EDV
IWRE=IRES/W
LOGF=LOG(0.0001)
IF (F.GT.0) LOGF=LOG(F)
Y=LOGF+EPS(1)
;GENERATE CMAX AT END OF INFUSION (DUR)
 IF(DUR.EQ.TT) CMAX=EXP(Y)

-- 
Paul R. Hutson, Pharm.D.
Associate Professor
UW School of Pharmacy
777 Highland Avenue
Madison WI 53705-2222
Tel  608.263.2496
Fax 608.265.5421
Pager 608.265.7000, p7856
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Received on Tue Apr 06 2010 - 14:22:28 EDT

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