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FW: negative iteration numbers in .ext files

From: Bachman, William <William.Bachman>
Date: Fri, 16 Apr 2010 09:11:07 -0400

 

-----Original Message-----
From: Ludden, Thomas
Sent: Friday, April 16, 2010 9:08 AM
To: Bachman, William
Subject: RE: [NMusers] negative iteration numbers in .ext files

 
Bill,

Pages 33 and 34, Introduction to NONMEM 7 (August 11, 2009) provide the
explanation regarding negative iteration values. Bob plans to add a
table of contents for a future release.

Tom
-----Original Message-----
From: owner-nmusers
On Behalf Of Bachman, William
Sent: Friday, April 16, 2010 8:09 AM
To: andreas.krause
Subject: RE: [NMusers] negative iteration numbers in .ext files

Andreas, you are not alone. We all have negative iterations. They are
just flags for the final parameter estimates (-1000000000) and their
standard errors (-1000000001) that can be used as parsing tags for other
programs.

I could not quickly find where this is documented.

Bill

-----Original Message-----
From: owner-nmusers
On Behalf Of andreas.krause
Sent: Friday, April 16, 2010 5:30 AM
To: nmusers
Subject: [NMusers] negative iteration numbers in .ext files

Does anyone else have the 'feature' of negative iteration numbers in the

.ext file that nonmem writes?
Mostly the values are similar or identical to the preceding lines but
not
always (see example below).
I am using nonmem 7.1.2 with gfortran 4.5.0, installed with nmqual 7.1.0

on Windows XP.

Thanks for any clues.

        Andreas


TABLE NO. 1: First Order Conditional Estimation with Interact
 ITERATION THETA1 THETA2 THETA3 THETA4
....OMEGA(10,10) OBJ
            0 2.70000E+02 7.00000E+01 7.00000E+00 3.00000E+00
0.00000E+00 17903.085422267555
           10 2.62990E+02 4.41321E+01 7.48823E+00 4.16453E+00
0.00000E+00 17596.998988682855
           20 2.30575E+02 7.98655E+01 7.36614E+00 1.19184E+01
0.00000E+00 17573.820822902107
           30 2.31353E+02 7.94068E+01 7.36395E+00 1.17636E+01
0.00000E+00 17573.797569595510
           40 2.31992E+02 7.88078E+01 7.38680E+00 1.16398E+01
0.00000E+00 17573.754599870816
  -1000000000 2.31992E+02 7.88078E+01 7.38680E+00 1.16398E+01
0.00000E+00 17573.754599870816
  -1000000001 1.27442E+01 1.15823E+01 1.56697E-01 3.27570E+00
1.00000E+10 0.0000000000000000





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Received on Fri Apr 16 2010 - 09:11:07 EDT

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