From: yhb5442387

Date: Thu, 22 Apr 2010 23:49:14 +0800 (CST)

Dear Sebastien:I have to say that my admiration to you is beyond the words,because you have directly pointed out the radical essence.Could the ke or the V/F,any one , be derived from the known Cmax,AUC,?As far as I have leaned ,the equations are as follows: AUC=Dose*F/Ke*V,Cmax=(F*Dose/V)*(exp(Ka*Tmax)-epx(Ke*Tmax)).After the computation and transformation ,I was obstructed in the front of the following: Ke-2.1*Ln(Ke)=3.18.something like that, well I could not remember the constant number (2.1 e.g.) clearly. I am not able to solve that equation.So,I decide to make some equations in the $PK,in which the CL V and Ka could all be expressed as the component of Tmax ,Cmax,and AUC at the same time.The suggestion you have made is usefull,but still a little problem :the Ke.Thank you for your generous help.22 03:24:55，"Sebastien Bihorel" <Sebastien.Bihorel

*>
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*>It looks like you are trying to derive the unknown values of KA, CL/F
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*>and V/F from the known values of Tmax, Cmax and AUC (probably obtained
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*>from a non compartmental analysis).
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*>
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*>If that is really the case, you will need to know the values of the
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*>half-life of elimination or the slope of elimination Ke to solve for Ka
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*>and V/F (the following solutions assume a one-compartment model with
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*>linear absorption and elimination):
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*>
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*>CL/F = Dose/AUC
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*>
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*>V/F = (CL/F)/Ke
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*>
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*>KA = - (1/tmax)*ln[ exp(-ke*tmax) - (Cmax*V)/(F*dose) ]
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*>
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*>If you don't know Ke, you will have to solve for V/F and Ka numerically,
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*>prior to your simulation.
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*>
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*>Sebastien
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*>
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*>yhb5442387 wrote:
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*>>
*

*>> Dear Nmuser:
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*>>
*

*>> I would like to do a data simulation .The distributions of the drug
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*>> population pharmaockinetics were assumed to be normal.But the profile
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*>> that I have got is Tmax, Cmax,and AUC(the means and variances are
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*>> already known),instead of Ka,CL,and V. What the $PK modification
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*>> should I have to do in the model where the advan2 has been taken in
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*>> the $subroutine.
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*>>
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*>> F=1.
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*>>
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*>> Any suggestion would be appreciated.
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*>>
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*>> Yours,ye hong bo
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*>>
*

*>>
*

*>>
*

*>>
*

*>> --
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*>> 工作和生活,都要开心的过.
*

*>> 你好,叶红波在此送上真挚的祝福.祝你开心,
*

*>> 叶红波
*

*>>
*

*>>
*

Date: Thu, 22 Apr 2010 23:49:14 +0800 (CST)

Dear Sebastien:I have to say that my admiration to you is beyond the words,because you have directly pointed out the radical essence.Could the ke or the V/F,any one , be derived from the known Cmax,AUC,?As far as I have leaned ,the equations are as follows: AUC=Dose*F/Ke*V,Cmax=(F*Dose/V)*(exp(Ka*Tmax)-epx(Ke*Tmax)).After the computation and transformation ,I was obstructed in the front of the following: Ke-2.1*Ln(Ke)=3.18.something like that, well I could not remember the constant number (2.1 e.g.) clearly. I am not able to solve that equation.So,I decide to make some equations in the $PK,in which the CL V and Ka could all be expressed as the component of Tmax ,Cmax,and AUC at the same time.The suggestion you have made is usefull,but still a little problem :the Ke.Thank you for your generous help.22 03:24:55，"Sebastien Bihorel" <Sebastien.Bihorel

-- 工作和生活,都要开心的过. 你好,叶红波在此送上真挚的祝福.祝你开心, 叶红波Received on Thu Apr 22 2010 - 11:49:14 EDT