NONMEM Users Network Archive

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Predict AUC based on trough concentrations

From: Hang, Yaming <yaming_hang>
Date: Wed, 17 Feb 2010 13:22:43 -0500

Dear NONMEM Users,

I have a study where I'd like to predict AUC based on 2~3 trough
concentrations. There are about 500 subjects and I intend to predict
drug concentration for 560 time points for each subject (10 time
points/day * 56 days). The EBE for model parameters for each individual
have been generated and they will be fed into NONMEM for calculation of
drug concentrations. The following is the relevant NONMEM code:

$INPUT ID DOSE=DROP DAYN TIME AMT DV EVID MDV ADDL II CONC CLI V2I Q3I
V3I Q4I V4I KAI F1I ALGI

$SUBROUTINES ADVAN12 TRANS4
$PK
  CL=CLI
  V2=V2I
  KA=KAI
  F1=F1I
  Q3=Q3I
  V3=V3I
  Q4=Q4I
  V4=V4I
  ALAG1=ALGI
  S2=V2I*624.709/1E6

$ERROR
   IPRED=F
   Y=F

$SIMULATION (26730517) ONLYSIMULATION SUBPROBLEMS=1

But I get error message like
0WARNING: MAXIMUM NUMBER OF THETA'S PLUS VARIANCE COMPONENTS
 EXCEEDS MAXIMUM NUMBER OF PARAMETERS THAT CAN BE ESTIMATED.
 SEE INSTALLATION GUIDE

I've increased LTH to 60 in file SIZES, LVR has a value of 30, but still
encounter this error message.

Does anybody have done similar thing in the past? What's likely to be
the true issue here? Your suggestion will be greatly appreciated.

Yaming

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Received on Wed Feb 17 2010 - 13:22:43 EST

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