# RE: Predict AUC based on trough concentrations

From: Sam Liao <sliao>
Date: Wed, 17 Feb 2010 12:28:49 -0800

Dear Yamin:

This is caused by the 560 time points that exceeded the max limit of
observations. For SIZE_big, the limit is 500 (see the partial codes below
for nm7). You need to change NO=500 to something bigger.

Sam Liao

Pharmax Research

============================================================================
==========

! NO: MAX NO. OF OBSERVATION RECORDS / INDIVIDUAL RECORD

! IF NO IS CHANGED, ALSO RECOMPILE NM-TRAN, NM-TRAN LIBRARY

PARAMETER (NO=500)! TL 4/22/09

From: owner-nmusers
Behalf Of Hang, Yaming
Sent: Wednesday, February 17, 2010 10:23 AM
To: nmusers
Subject: [NMusers] Predict AUC based on trough concentrations

Dear NONMEM Users,

I have a study where I'd like to predict AUC based on 2~3 trough
concentrations. There are about 500 subjects and I intend to predict drug
concentration for 560 time points for each subject (10 time points/day * 56
days). The EBE for model parameters for each individual have been generated
and they will be fed into NONMEM for calculation of drug concentrations. The
following is the relevant NONMEM code:

\$INPUT ID DOSE=DROP DAYN TIME AMT DV EVID MDV ADDL II CONC CLI V2I Q3I V3I
Q4I V4I KAI F1I ALGI

\$PK
CL=CLI
V2=V2I
KA=KAI
F1=F1I
Q3=Q3I
V3=V3I
Q4=Q4I
V4=V4I
ALAG1=ALGI
S2=V2I*624.709/1E6

\$ERROR
IPRED=F
Y=F

\$SIMULATION (26730517) ONLYSIMULATION SUBPROBLEMS=1

But I get error message like
0WARNING: MAXIMUM NUMBER OF THETA'S PLUS VARIANCE COMPONENTS
EXCEEDS MAXIMUM NUMBER OF PARAMETERS THAT CAN BE ESTIMATED.
SEE INSTALLATION GUIDE

I've increased LTH to 60 in file SIZES, LVR has a value of 30, but still
encounter this error message.

Does anybody have done similar thing in the past? What's likely to be the
true issue here? Your suggestion will be greatly appreciated.

Yaming

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