NONMEM Users Network Archive

Hosted by Cognigen

How to calculate t1/2, z?

From: Li Y. Chen <yicong2005>
Date: Mon, 22 Feb 2010 08:16:42 -0800

I have a three-compartment model. Dose anyone know how to calculate the
terminal half life (t1/2, Z) using the finial estimates (V2, V3, V4, CL2,
CL3, and CL4)?

t1/2, z= ln2*Varea/CL, should Varea =V2+V3+V4? How about CL?

Thank you!


Received on Mon Feb 22 2010 - 11:16:42 EST

The NONMEM Users Network is maintained by ICON plc. Requests to subscribe to the network should be sent to:

Once subscribed, you may contribute to the discussion by emailing: