NONMEM Users Network Archive

Hosted by Cognigen

Meta-analysis with Nonmem

From: alindauer-research
Date: Wed, 24 Feb 2010 10:08:11 +0100


I wanted to investigate the dose-response relationship (Emax model) of a
drug with NONMEM, based on data from literature (i.e. a meta-analysis).
However, I am not quite sure how to deal with the different levels of
random effects. Suppose I have 10 studies of different size where
different doses were given and the response is presented as average change =

of a biomarker +/- standard deviation for each dose level. How would I
incorporate the standard deviation of the biomarker measurements reported
in each study for each dose level and how would I account for the
different number of patients in the study?
I would greatly appreciate your help, maybe with a NM-code snippet or
reference to a paper where something similar has been done.

Thanks in advance, Andreas.

Andreas Lindauer
Pharmacokinetics and Metabolism
R&D Center. Ferrer Internacional S.A.
Juan de Sada 32, 08028 Barcelona


¿Necesita imprimir este mensaje? Protejamos el medio ambiente.
Li cal imprimir aquest missatge? Protegim el medi ambient.
Do you need to print this message? Let's protect the environment.

Este mensaje, y en su caso, cualquier fichero anexo al mismo, puede
contener información confidencial, siendo para uso exclusivo del
destinatario, quedando prohibida su divulgación, copia o distribución a=
terceros sin la autorización expresa del remitente. Si Vd. ha recibido
este mensaje erróneamente, se ruega lo notifique al remitente y proceda a=
su borrado. Gracias por su colaboración.

This message and its annexed files may contain confidential information
which is exclusively for the use of the addressee. It is strictly
forbidden to distribute copies to third parties without the explicit
permission of the sender. If you receive this message by mistake, please
notify it to the sender and make sure to delete it. Thank you for your
kind cooperation.

(image/gif attachment: 01-part)

(image/gif attachment: 02-part)

Received on Wed Feb 24 2010 - 04:08:11 EST

The NONMEM Users Network is maintained by ICON plc. Requests to subscribe to the network should be sent to:

Once subscribed, you may contribute to the discussion by emailing: