NONMEM Users Network Archive

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Meta-analysis with Nonmem

From: alindauer-research
Date: Wed, 24 Feb 2010 10:08:11 +0100

Dear NMUSERS,

I wanted to investigate the dose-response relationship (Emax model) of a
drug with NONMEM, based on data from literature (i.e. a meta-analysis).
However, I am not quite sure how to deal with the different levels of
random effects. Suppose I have 10 studies of different size where
different doses were given and the response is presented as average change =

of a biomarker +/- standard deviation for each dose level. How would I
incorporate the standard deviation of the biomarker measurements reported
in each study for each dose level and how would I account for the
different number of patients in the study?
I would greatly appreciate your help, maybe with a NM-code snippet or
reference to a paper where something similar has been done.

Thanks in advance, Andreas.


Andreas Lindauer
Pharmacokineticist
Pharmacokinetics and Metabolism
R&D Center. Ferrer Internacional S.A.
Juan de Sada 32, 08028 Barcelona


alindauer-research
www.ferrergrupo.com







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Received on Wed Feb 24 2010 - 04:08:11 EST

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