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Re: how to implement AR residual error model in Nonmem with FOCE INT routine

From: nonmem
Date: Wed, 06 Jan 2010 15:13:15 +0000 (GMT)

Hello Nonmem Users,

Is there a more detailed explanation of the code in



http://cognigencorp.com/nonmem/nm/97dec172003.html somwhere? I try to implement a second-order autoregressive process. If C(J,1) is a correlation coefficient, can I use more complex equations for C(j,1)? Will this code work if we use ADVAN13 (PD model here)?

Thanks!
Pavel




----- Original Message -----
From: Gastonguay, Marc
Date: Tuesday, December 29, 2009 10:09 am
Subject: Re: [NMusers] how to implement AR residual error model in Nonmem with FOCE INT routine
To: Ethan Wu
Cc: nmusers

> Hello Ethan,
> This archived NMusers discussion thread might be useful:
>
> http://cognigencorp.com/nonmem/nm/97dec172003.html
>
> Marc
>
> Marc R. Gastonguay, Ph.D.
> President & CEO, Metrum Research Group LLC < metrumrg.com >
> Scientific Director, Metrum Institute < metruminstitute.org >
> 2 Tunxis Rd, Suite 112, Tariffville, CT 06081 Direct:
> +1.860.670.0744 Main: +1.860.735.7043 Fax: +1.860.760.6014
>
>
>
> On Dec 29, 2009, at 9:14 AM, Ethan Wu wrote:
>
> > Dear all,
> > I am fitting a PK/PD model using FOCE INT. I do see a high
>
> > correlation between WRES
> > I wonder could someone help me with implementation of AR
> residual
> > error model in NONMEM.
> > Many thanks! Happy new year to all.
> >
> >
>
>

Received on Wed Jan 06 2010 - 10:13:15 EST

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