NONMEM Users Network Archive

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PD model

From: chenyuhong
Date: Thu, 14 Jan 2010 01:44:46 GMT

Dear All,
I am looking for a help. Currently I am working on a population PD model=
 to evaluate the effects of drugs on QT prolongation. Drug A and drug B=
 are given to the study subjects (healthy volunteer) at the same time. D=
rug B is the inhibitor for the metabolism of drug A, also compound C is =
the metabolite of drug A. I am wondering how to evaluate the effects fo=
r drug A or B or the metabolite of drug A (compound C). These three moie=
ties will be present together in the blood for most of the time. Is anyo=
ne has experience and would like to share with us. Any comment will be g=
reatly appreciated.
Best regards,

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Received on Wed Jan 13 2010 - 20:44:46 EST

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