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Post-doctoral fellowship in Disease Modelling - Neurodegeneration

From: oscar.e.della-pasqua
Date: Thu, 14 Jan 2010 17:51:12 +0000

Clinical Pharmacology Modelling & Simulation (CPMS)

CPMS has a leading position within clinical development at
GlaxoSmithKline, contributing to the very first administration of a
compound to humans and for demonstrating clinical efficacy in patients or
other relevant population. Within CPMS, the Development & Technologies
Group provide core methodological support and infrastructure pertinent to
modelling and simulation activities. In addition, it offers expert advice
to physicians and clinical scientists within the clinical R&D

Innovative Medicines Initiative (IMI)

At present, CPMS is actively involved in a major research initiative under=
the auspices of the Innovative Medicines Initiative (, a consortium between industry and academia
which aims at identification of biomarkers for Alzheimer?s disease

We now have an opportunity for a Post-doctoral Fellow to join the team at
our West London site in the UK. In this position you will contribute to
the modelling of potential markers of neurodegeneration and optimisation
of experimental and clinical study design for endpoints associated with
cognitive function. Bringing together European experts in translational
medicine, drug discovery and mathematical modelling, PHARMA-COG proposes
to develop models of disease progression and validate pharmacodynamic
markers to support dose selection.

The candidate will work in close collaboration with other partners in the
consortium and will provide technical advice on modelling issues which may=
arise during data analysis. The results of the research will be submitted
for publication in scientific journals.

Our preferred candidate

- holds a PhD, MD or equivalent knowledge level within medicine, clinical
pharmacology, physiology, bio-engineering, pharmacometrics or related
disciplines with relevant experience in pharmacokinetic-pharmacodynamic
- is an advanced user or proficient in computer programs routinely used
in modelling and simulation like R, WinBUGS, NONMEM, SAS.
- has interest in and knowledge of both the mathematical and physiological=
aspects of modelling/simulation in drug development.
- is enthusiastic and has good personal communication skills and the drive=
to interact successfully with colleagues at all levels.

Excellent presentation and writing skills in English are required.


Candidates can apply online (, req ID 56565) by January
30, 2010 or email your CV and motivation letter to Claire Jones
This e-mail was sent by GlaxoSmithKline Services Unlimited
(registered in England and Wales No. 1047315), which is a
member of the GlaxoSmithKline group of companies. The
registered address of GlaxoSmithKline Services Unlimited
is 980 Great West Road, Brentford, Middlesex TW8 9GS.

Received on Thu Jan 14 2010 - 12:51:12 EST

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