NONMEM Users Network Archive

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Significant Figures Continuation

From: Indranil Bhattacharya <ibhattacharya>
Date: Wed, 20 Jan 2010 09:21:23 -0500

First, of all sorry about the last email, it somehow got sent before I could
complete it.


Hi, while running a KOKA model I came across an observation and would
greatly appreciate it if someone helps me understand it.
When using a SIG=3, the model converges, and provides lower and upper CI
bounds. All the CI bounds are positive except Q and the CV% of all
parameters are within 20 % (except Q).
This suggests (correct me if I am wrong) that the data might not be rich
enough for the model to calculate a precise value for Q so it gives a wider
range?
Now when I change the SIG=3 to SIG=4, the model converges but the CV% are
very high and more importantly I get negative lower bounds for all the
parameters. What does this suggest, that the model cannot get precise
estimates now at the level of significance (of numbers) requested? Please
advise.

Regards

Neil

--
Indranil Bhattacharya




--
Indranil Bhattacharya

Received on Wed Jan 20 2010 - 09:21:23 EST

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