NONMEM Users Network Archive

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RE: EHC modelling

From: Masoud Jamei <masoud.jamei>
Date: Thu, 28 Jan 2010 01:06:34 -0000

Hi Joan


You may find the following papers useful.


Jiao Z, Ding JJ, Shen J, Liang HQ, Zhong LJ, Wang Y, Zhong MK and Lu WY
(2008) Population pharmacokinetic modelling for enterohepatic circulation of
mycophenolic acid in healthy Chinese and the influence of polymorphisms in
UGT1A9. Br J Clin Pharmacol 65:893-907.


Yau W-P, Vathsala A, Lou H-X, Zhou S and Chan E (2009) Mechanism-Based
Enterohepatic Circulation Model of Mycophenolic Acid and Its Glucuronide
Metabolite: Assessment of Impact of Cyclosporine Dose in Asian Renal
Transplant Patients. J Clin Pharmacol 49:684-699.


Also, please note that gallbladder is not getting fully emptied when it
contracts and the emptying process is not abrupt. In addition, there are
cases where a part of metabolite may return to the parent form
(deconjugated) when it reaches the small intestine.






Received on Wed Jan 27 2010 - 20:06:34 EST

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