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Pharmacometrics and Clinical Pharmacology positions at Pfizer

From: Milligan, Peter A <peter.a.milligan>
Date: Thu, 28 Jan 2010 10:32:40 -0000

Have a positive effect.


With the strongest R&D pipeline in the pharmaceutical industry, this is
an exciting time to be at Pfizer. Both our Pharmacometricians and
Clinical Pharmacology Leads have key roles to play in influencing the
discovery and development of drugs. It's fascinating, vital work and
you could be part of it. We have made the strategic decision to
significantly increase our workforce in these disciplines because of
their critical importance to our organization. Therefore we have
several new positions for talented individuals at our various sites.


Pharmacometricians (all grades from Manager to Executive Director) at
various locations in the USA (Collegeville, PA; Groton, CT; La Jolla,
CA) and UK (Sandwich, Kent)


In this key role as a member of our Global Pharmacometrics group you
will be responsible for providing expert study/program design, data
analytical and interpretation inputs to our various Research and
Business Unit (RU/BU) organizations. The successful candidates will work
as partners of disease area aligned multi-disciplinary teams in
providing model based drug development expertise and leadership to a
variety of drug discovery and development programs through to loss of
patent exclusivity. Of key importance will be the formation and
maintenance of effective collaborations with amongst others,
statistical, clinical and clinical pharmacology members of these teams.


Pharmacometricians provide strategic input into pre-clinical discovery,
development and post-approval plans quantifying the risk associated with
particular study designs or program strategies and
communicating/dissemination of the results. They are responsible for the
use of a variety of innovative quantitative methods to integrate
knowledge of pharmacokinetics, a variety of response variables
(including pharmacodynamic, clinical outcome and undesirable effects),
patient characteristics and disease mechanism/states, statistics,
study/experimental design, clinical trial simulations, meta-analytical
evidence synthesis and quantitative techniques to facilitate
quantitative decision making thereby increasing RU/BU efficiency.


In addition to the disease specific project activities the successful
candidates will forge collaborative relationships with Pharmacometric
colleagues within the global Pharmacometrics community (currently based
in USA, UK, China and Japan), other subject matter specialists and
groups external to the organization (leading academics, external service
providers etc.). The successful candidates will work with colleagues to
ensure Pfizer's position as a leader in the use of quantitative
approaches supporting drug development strategies and worldwide
registration of new medicines.


Clinical Pharmacology Lead (all grades from Manager to Senior Director)
at various locations in the USA (Cambridge, MA; Collegeville, PA;
Groton, CT; La Jolla, CA; New York, NY) and UK (Sandwich, Kent)


In this key role you will serve as the Clinical Pharmacology
representative on multidisciplinary development teams and provides
clinical pharmacology expertise and leadership to a project. In the
research units the position entails partnering with research based
colleagues to select and validate targets and ensure that sufficient
pre-clinical PK-PD knowledge exists to underwrite safe human
administration and integrate this and early human data in order to
design efficient and informative proof of mechanism and proof of concept
studies. In the business units, the position entails partnering with
development colleagues to integrate prior knowledge in order to develop
innovative clinical development strategies and study designs for Phase
II-IV clinical trials by applying the principles of model based drug


Clinical Pharmacology Leads work closely with clinicians and
statisticians to create clinical development plans that include
assessments of a drug's efficacy, safety, commercial viability and
fulfillment of registration requirements. The Clinical Pharmacology Lead
is primary responsibility for the clinical pharmacology components of
the development plan.


In order to achieve these aims, candidates are responsible for the use
of innovative analytical methods to integrate knowledge of
pharmacokinetics, biopharmaceutics, pharmacodynamics, patient
characteristics and disease states to optimize doses, dosage regimens
and study designs throughout clinical drug development (including FIH
single/multiple doses, proof of concept PK-PD, dose-ranging in
patients, pivotal efficacy/safety, drug interactions, special
populations, food effects, etc) providing clinical pharmacology support
and leadership in the preparation and defense of regulatory submissions.


Both Clinical Pharmacology Leads and Pharmacometricians routinely
interact with internal governance bodies, regulatory agencies and
external opinions leaders. They are expected to influence the external
environment by advancing their discipline and through external
presentations and publications.


The ideal candidates will have a doctorate degree with demonstrated
expertise in clinical pharmacology and/or pharmacometrics and strong
quantitative skills (e.g. experience in mechanistic modeling/systems
pharmacology, quantitative translational scaling, literature
meta-analyses, population modeling, and clinical trial simulations). We
encourage applicants from different disciplines including pharmaceutical
sciences, biostatistics, medicine, engineering, etc. Candidates with
significant experience are sought as well as recent graduates. In
addition to professional challenge, we offer a culture that supports and
encourages ideas, and recognizes individual contribution. Moreover, the
salary and extensive benefits are everything you'd expect from a world
leading company


To apply please visit the careers pages on
<> and enter the following job opening numbers:


For Pharmacometrics, job opening number: 936303

For Clinical Pharmacology job opening number: 937333

Received on Thu Jan 28 2010 - 05:32:40 EST

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