NONMEM Users Network Archive

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RE: distribution assumption of Eta in NONMEM

From: Bachman, William <William.Bachman>
Date: Tue, 1 Jun 2010 12:07:44 -0400

I don't recall the context in which this was said, but, I remember
Stuart Beal saying something to the effect of "the assumption of
normality of distributions is not a strict one and that NONMEM works
quite well as long as the distributions are relatively symmetrical". I
will leave the interpretation to the rest of you.


From: owner-nmusers
On Behalf Of Ethan Wu
Sent: Tuesday, June 01, 2010 10:04 AM
To: Ribbing, Jakob; nmusers
Subject: Re: [NMusers] distribution assumption of Eta in NONMEM

Dear Jakob and all,
    In this thread, Mats clearly indicated Eta is assumed normal
distributed. But, others have said differently.
    I wonder which statement is correct?


From: Ribbing, Jakob <Jakob.Ribbing
To: nmusers <nmusers
Sent: Tue, June 1, 2010 3:10:44 AM
Subject: RE: [NMusers] distribution assumption of Eta in NONMEM

Dear all,


Dropping in a little late in the game all I can say is this:

Shame on all you great minds for reinventing your own wisdom :>)


Most of the content in the current thread has already been discussed in
an earlier thread:


However, this old thread does contain a lot of postings and quite a few
which are VERY confusing, so you may want to skip ahead to Matt's
posting here:

(There are also many other postings which are very useful, but the one
above captures the essence with regards to the original question in the
current thread)


That said I think there are always new learnings in each thread, as
people tend to express themselves differently and the original question
branch into several new discussion points.

So I guess there are never two threads that are exactly alike, even when
the usual suspects participate in both.







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Received on Tue Jun 01 2010 - 12:07:44 EDT

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