NONMEM Users Network Archive

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RE: Bayesian estimates of multiple occasions

From: Sam Liao <sliao>
Date: Thu, 3 Jun 2010 09:27:22 -0700

Dear Markus:

The error message indicated that you need to use EVID=4 to reset your system
in the second dose event.

 

Sam Liao

Pharmax Research Inc.

 

From: owner-nmusers
Behalf Of markus joerger
Sent: Thursday, June 03, 2010 8:20 AM
To: nmusers
Subject: [NMusers] Bayesian estimates of multiple occasions

 

dear NONMEM community,

I'd like to estimate the potential value of individual dose adaptations of
an anticancer drug by applying Bayesian POSTHOC (individual) estimates on a
previous model. As I have data on the interoccasion variability, I put "OCC"
into the table for the Bayesian run, but NONMEM seems not to accept two
occasions for POSTHOC-only:

""0DATA REC 31: TIME DATA ITEM IS LESS THAN PREVIOUS TIME DATA ITEM
0DATA REC 51: TIME DATA ITEM IS LESS THAN PREVIOUS TIME DATA ITEM""

I'd guess that >1 occasion should also work with POSTHOC-only, with an
adequate input of IOV and residual variability. Otherwise, it might be
necessary
to code two time-separate dosing events within one time-scale? Can anybody
explain?

thanks and kind regards,

Markus

my table looks like that:
----------------------------------------------------------------------------
-------------------

C, ID, OCC, TIME, AMT, RATE, DV, CMT, MDV, EVID, AGE, BILI, BSA, SEX


--
Markus Joerger MD PhD
Department of Medical Oncology
Rorschacherstr. 95
9007 St. Gallen
Switzerland
markus.joerger
markus.joerger
phone: +41-765591070
fax: +41-714946368


Received on Thu Jun 03 2010 - 12:27:22 EDT

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