NONMEM Users Network Archive

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Re: help on a minimization problem

From: Sebastien Bihorel <Sebastien.Bihorel>
Date: Fri, 18 Jun 2010 11:10:49 -0400
Hi Ethan,

You have reached the maximum number of function evaluation (9999 I believe). Two solutions:
1- you create a copy of your control stream and update the initial estimates with the 'final' estimates of your first run
2- you create a copy of your control stream and use an $MSFI statement in case you would have use the MSFO option in your first run.

Then, run the copied control stream. Hopefully, your run will converge before reached the maximum number of function evaluation.

HIH

Sebastien

Ethan Wu wrote:
Hi users,
  I ran into this error with a analyis using PRED routine.
0MINIMIZATION TERMINATED
 DUE TO MAX. NO. OF FUNCTION EVALUATIONS EXCEEDED
 NO. OF FUNCTION EVALUATIONS USED:    10093
 NO. OF SIG. DIGITS UNREPORTABLE
I did find in previous discussion, people suggested to do by adding this under $PK
" FIRST
" COMMON /PRCOMG/ IDUM1,IDUM2,IMAX,IDUM4,IDUM5
" INTEGER IDUM1,IDUM2,IMAX,IDUM4,IDUM5
" IMAX=100000
but, when I added above below $PRED,  it didn't work.
Any suggestion? Thanks.

Received on Fri Jun 18 2010 - 11:10:49 EDT

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