NONMEM Users Network Archive

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Re: help on a minimization problem

From: Nick Holford <n.holford>
Date: Fri, 18 Jun 2010 22:28:38 +0200

Ethan,

There are (at least) two kinds of evaluations/iterations you need to be
aware of when using NONMEM.

1. The number of function evaluations which is a way of limiting the
total work that NONMEM tries to make during estimation. It is determined
by the estimation option MAXEVAL.

2. The number of iterations used by the differential equation solver
when trying to make a step from one data record to the next.

The problem you report is with the number of function evaluations. In
NM7 you can specify a number larger than 10000 to ask NONMEM to do more
work.

The verbatim code trick you tried works with NMVI but not with NM7 to
increase the number of differential equation solver iterations. Does
anybody know how to get NM7 to try harder to solve differential equations?

Nick


Ethan Wu wrote:
> Hi users,
> I ran into this error with a analyis using PRED routine.
> 0MINIMIZATION TERMINATED
> DUE TO MAX. NO. OF FUNCTION EVALUATIONS EXCEEDED
> NO. OF FUNCTION EVALUATIONS USED: 10093
> NO. OF SIG. DIGITS UNREPORTABLE
> I did find in previous discussion, people suggested to do by adding
> this under $PK
> " FIRST
> " COMMON /PRCOMG/ IDUM1,IDUM2,IMAX,IDUM4,IDUM5
> " INTEGER IDUM1,IDUM2,IMAX,IDUM4,IDUM5
> " IMAX=100000
> but, when I added above below $PRED, it didn't work.
> Any suggestion? Thanks.
>

--
Nick Holford, Professor Clinical Pharmacology
Dept Pharmacology & Clinical Pharmacology
University of Auckland,85 Park Rd,Private Bag 92019,Auckland,New Zealand
tel:+64(9)923-6730 fax:+64(9)373-7090 mobile:+64(21)46 23 53
email: n.holford
http://www.fmhs.auckland.ac.nz/sms/pharmacology/holford


Received on Fri Jun 18 2010 - 16:28:38 EDT

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