NONMEM Users Network Archive

Hosted by Cognigen

AW: Meta-analysis with Nonmem

From: Garmann, Dirk <Dirk.Garmann>
Date: Thu, 4 Mar 2010 12:13:43 +0100

Dear Guangli,
You can use normal distribution as an assumption and simulate N individua=
ls with one observation per individual based on the given N, mean and SD.=
 Then, the values calculated based on simulated data should be similar to=
 the used literature data. The combined dataset based on different studie=
s (with N, mean, SD) should reflect the "real" situation.
You can use this dataset to develop a base PK/PD model
However, any covariate relationship will not be considered

I full agree with Nick to use the parameter itself instead of CFB. If you=
 have different studies, some with CFB, some with Baseline and the parame=
ter itself, a solution might be to use CFB and consider baseline as a cov=

Best regards

Dirk Garmann, PhD
Clinical Scientific Expert /Pharmacokineticist
Merz Pharmaceuticals
Eckenheimer Landstrasse 100
60318 Frankfurt
Phone +49 (69) 1503 720

Von: Guangli Ma [mailto:guangli.pmx
Gesendet: Thursday, March 04, 2010 3:18 AM
An: Garmann, Dirk
Cc: nmusers
Betreff: Re: [NMusers] Meta-analysis with Nonmem

Dear Dirk,

    I haven't fully understood your idea. Mean value, SD, and N can be co=
llected from literature. But if we don't have a model, how can we simulat=
e one individual with many observations?
    I met a problem and haven't got a solution. I chose change from basel=
ine as endpoint. But some literatures didn't provide CFB. The CFB and SD =
of CFB calculated from mean value and SD are different from the values ca=
lculated from individual data. Your suggestion will be highly appreciated=
. Thanks.

Best regards,

Merz Pharmaceuticals GmbH, Frankfurt am Main
Amtsgericht Frankfurt am Main, HRB 53808
Geschäftsführung: Dr. Martin Zügel (Vors.), Dr. Alexander Gebauer,
Dr. Karsten Schlemm, Dr. Eugen Wilbert

Die vorgenannten Angaben der E-Mail haben grundsätzlich nur informative=
n Charakter. Dies ist kein Anerkenntnis, dass es sich beim Inhalt dieser =
E-Mail um eine rechtsverbindliche Erklärung der entsprechenden Gesellsc=
haft der Merz Gruppe handelt, es sei denn dies ist ausdrücklich als sol=
ches formuliert. Erklärungen, die eine Gesellschaft der Merz Gruppe ver=
pflichten sollen, bedürfen jeweils der Unterschrift durch zwei zeichnun=
gsberechtigte Personen dieser Gesellschaft.
Diese E-Mail enthält vertrauliche und/oder rechtlich geschützte Info=
rmationen. Wenn Sie nicht der richtige Adressat sind oder diese E-Mail ir=
rtümlich erhalten haben, informieren Sie bitte sofort den Absender und=
 vernichten Sie diese E-Mail. Das unerlaubte Kopieren sowie die unbefugt=
e Weitergabe dieser E-Mail ist nicht gestattet.

This e-mail may contain confidential and/or privileged information. If y=
ou are not the intended recipient (or have received this e-mail in error=
) please notify the sender immediately and destroy this email. Any unaut=
horised copying, disclosure or distribution of the material in this e-ma=
il is strictly forbidden. (MRZ/2010)
Received on Thu Mar 04 2010 - 06:13:43 EST

The NONMEM Users Network is maintained by ICON plc. Requests to subscribe to the network should be sent to:

Once subscribed, you may contribute to the discussion by emailing: