NONMEM Users Network Archive

Hosted by Cognigen

RE: Questions about the raw output file in NM7

From: Bauer, Robert <Robert.Bauer>
Date: Wed, 10 Mar 2010 20:01:20 -0500

I would recommend the following:

1. Set PRINT=9999

This way, iteration 0 is printed, as well as the final results.
Unlikely you will have more than 9999 iterations to have any intervening
iterations printed.

2. Do not specify the FILE= in a multi-problem statement such as the
$SIML NSUB=3 type. The .ext file name will be defaulted to the root
name of your control stream file, so you do not have control of its
name, but it should not be over-written from one problem to the next, or
in a multi-problem statement.

Robert J. Bauer, Ph.D.
Vice President, Pharmacometrics
ICON Development Solutions
Tel: (215) 616-6428
Mob: (925) 286-0769
Email: Robert.Bauer

-----Original Message-----
From: owner-nmusers
On Behalf Of Sebastien Bihorel
Sent: Wednesday, March 10, 2010 4:28 PM
To: nmusers
Subject: [NMusers] Questions about the raw output file in NM7

Dear NMusers,

I would like to have your help on two issues regarding the raw output
file in NM7:

1- when using $ESTIMATION PRINT=0 with "old" estimation methods (FO,
FOCE, FOCEI, HYBRID and Laplacian), the raw output files only contain
the -1000000000 line plus possibly the -1000000001, -1000000002 and
-1000000003 lines. With new estimation methods, the files also contain
data at iteration 0. Is there an option we can use with old estimation
method to request the iteration 0 data to be written into the raw output


2- when an estimation step is requested after a simulation step with
NSUB>1, the raw output file only reports the result of the last
simulation/estimation run. E.g. when I tried the following code,

$SIM (1212345) NSUB=3

only TABLE NO. 3 was reported in whatever.est. By stopping the run at
different times, I found out that the content of the file is actually
overwritten at each sub-problem. Is there a option that would append the

new content to the file rather than overwriting it?

Thank you in advance for your feedback.

Sebastien Bihorel
ICON plc made the following annotations.
This e-mail transmission may contain confidential or legally privileged i=
that is intended only for the individual or entity named in the e-mail ad=
dress. If you
are not the intended recipient, you are hereby notified that any disclosu=
re, copying,
distribution, or reliance upon the contents of this e-mail is strictly pr=
ohibited. If
you have received this e-mail transmission in error, please reply to the =
sender, so that
ICON plc can arrange for proper delivery, and then please delete the mess=
Thank You,
ICON plc
South County Business Park
Dublin 18
Registered number: 145835

Received on Wed Mar 10 2010 - 20:01:20 EST

The NONMEM Users Network is maintained by ICON plc. Requests to subscribe to the network should be sent to:

Once subscribed, you may contribute to the discussion by emailing: