NONMEM Users Network Archive

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Re: Questions about the raw output file in NM7

From: Sebastien Bihorel <Sebastien.Bihorel>
Date: Thu, 11 Mar 2010 09:59:44 -0500

Thank you Robert for your reply. It is very helpful.

Bauer, Robert wrote:
> I would recommend the following:
>
> 1. Set PRINT=9999
>
> This way, iteration 0 is printed, as well as the final results.
> Unlikely you will have more than 9999 iterations to have any intervening
> iterations printed.
>
> 2. Do not specify the FILE= in a multi-problem statement such as the
> $SIML NSUB=3 type. The .ext file name will be defaulted to the root
> name of your control stream file, so you do not have control of its
> name, but it should not be over-written from one problem to the next, or
> in a multi-problem statement.
>
>
> Robert J. Bauer, Ph.D.
> Vice President, Pharmacometrics
> ICON Development Solutions
> Tel: (215) 616-6428
> Mob: (925) 286-0769
> Email: Robert.Bauer
> Web: www.icondevsolutions.com
>
>
>
> -----Original Message-----
> From: owner-nmusers
> On Behalf Of Sebastien Bihorel
> Sent: Wednesday, March 10, 2010 4:28 PM
> To: nmusers
> Subject: [NMusers] Questions about the raw output file in NM7
>
> Dear NMusers,
>
> I would like to have your help on two issues regarding the raw output
> file in NM7:
>
> 1- when using $ESTIMATION PRINT=0 with "old" estimation methods (FO,
> FOCE, FOCEI, HYBRID and Laplacian), the raw output files only contain
> the -1000000000 line plus possibly the -1000000001, -1000000002 and
> -1000000003 lines. With new estimation methods, the files also contain
> data at iteration 0. Is there an option we can use with old estimation
> method to request the iteration 0 data to be written into the raw output
>
> files?
>
> 2- when an estimation step is requested after a simulation step with
> NSUB>1, the raw output file only reports the result of the last
> simulation/estimation run. E.g. when I tried the following code,
>
> $SIM (1212345) NSUB=3
> $ESTIMATION METHOD=COND FILE=whatever.est PRINT=1 MAXEVAL=5000 NOABORT
>
> only TABLE NO. 3 was reported in whatever.est. By stopping the run at
> different times, I found out that the content of the file is actually
> overwritten at each sub-problem. Is there a option that would append the
>
> new content to the file rather than overwriting it?
>
> Thank you in advance for your feedback.
>
> Sebastien Bihorel
> ICON plc made the following annotations.
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Received on Thu Mar 11 2010 - 09:59:44 EST

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