NONMEM Users Network Archive

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nm7 IMP method question

From: Ethan Wu <ethan.wu75>
Date: Wed, 12 May 2010 07:13:53 -0700 (PDT)

Dear users,   I recently started using IMP methods offered by nm7. =
 In the first IMP step,  I had 100 iterations and the OBJ was quite sta=
ble already around 20 iterations. In the second IMP step to obtain SE of =
the estimate, as "$EST METHOD=IMP EONLY=1 INTERACTION  NOABORT N=
ITER=20 SIGL=4 NSIG=1 PRINT=1 ISAMPLE=300 DF=4 IACCEPT=1", =
the OBJ value kept increasing as iteration moved. at the end, the SE for th=
e model parameter estimate was not bad (<50%RES)  could someone help me=
 understand why OBJ continue increasing in the second IMP step? thanks.=
Received on Wed May 12 2010 - 10:13:53 EDT

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