NONMEM Users Network Archive

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Re: nm7 IMP method question

From: Ethan Wu <ethan.wu75>
Date: Wed, 12 May 2010 12:35:51 -0700 (PDT)

Hi Sebastian,   sorry just reply now, somehow your email was spamed, I =
just recovered after seeing other users reply to your email.   the r=
eason I had another IMP step was,  I remembered at nm7 workship, it was s=
uggested to run another IMP step for  SE estimate.   The first IMP wa=
s done as $EST METHOD=IMP INTERACTION  NOABORT NITER=100 CTYPE=3 =
PRINT=1 SIGL=4 ISAMPLE=300 ____________________________=
____ From: Sebastian Ueckert <sebastian.ueckert
ers <nmusers
t: Re: [NMusers] nm7 IMP method question Dear Ethan. if you use the =
IMP method to estimate your parameters, you do not have to run a second IMP=
 step. The ESTEP is run for every iteration and if the OFV is stable during=
 the last iterations you can just use that. However the behavior you are de=
scribing is strange. It could be related to different settings for both ste=
ps. Can you please send the code for both $EST lines? Best regards, =
Sebastian Sebastian Ueckert, MSc, PhD student -------------------=
---------------------------- Pharmacometrics Research Group, Department=
 of Pharmaceutical Biosciences, Uppsala University --------------------=
--------------------------- P.O. Box 591 SE-751 24 Uppsala Sweden -=
---------------------------------------------- sebastian.ueckert
uu.se ----------------------------------------------- Work:   +46-(0)=
18-471 4437 On Wed, May 12, 2010 at 4:13 PM, Ethan Wu <ethan.wu7=
5
Received on Wed May 12 2010 - 15:35:51 EDT

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