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RE: nm7 IMP method question

From: Standing Joseph <joseph.standing >
Date: Thu, 13 May 2010 08:14:23 +0100

Desr Ethan,

It is my understanding that you should do an IMP step with EONLY=1 in ord=
er to get an OFV to be used for hypothesis testing after a SAEM step, as th=
e SAEM OFV cannot be used for likelihood ratio tests. I think your problem=
 is that the first IMP step has converged (you asked for CTYPE=3), but in=
 the second IMP step you are not specifying any convergence criteria causin=
g your OFV to wander off (excuse the technical language).
Best wishes,


Joseph F Standing
Department of Pharmacy
Great Ormond Street Hospital for Children
London WC1N 3JH
From: owner-nmusers
 Of Ethan Wu [ethan.wu75
Sent: 12 May 2010 20:35
To: Sebastian Ueckert; nmusers
Subject: Re: [NMusers] nm7 IMP method question

Hi Sebastian,
  sorry just reply now, somehow your email was spamed, I just recovered aft=
er seeing other users reply to your email.

  the reason I had another IMP step was, I remembered at nm7 workship, it =
was suggested to run another IMP step for SE estimate.
  The first IMP was done as
=4 ISAMPLE=300

From: Sebastian Ueckert <sebastian.ueckert
To: nmusers <nmusers
Sent: Wed, May 12, 2010 11:08:09 AM
Subject: Re: [NMusers] nm7 IMP method question

Dear Ethan.
if you use the IMP method to estimate your parameters, you do not have to r=
un a second IMP step. The ESTEP is run for every iteration and if the OFV i=
s stable during the last iterations you can just use that. However the beha=
vior you are describing is strange. It could be related to different settin=
gs for both steps. Can you please send the code for both $EST lines?

Best regards,

Sebastian Ueckert, MSc, PhD student
Pharmacometrics Research Group,
Department of Pharmaceutical Biosciences,
Uppsala University
P.O. Box 591
SE-751 24 Uppsala
Work: +46-(0)18-471 4437

On Wed, May 12, 2010 at 4:13 PM, Ethan Wu <ethan.wu75


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Received on Thu May 13 2010 - 03:14:23 EDT

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