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12th Fisher/Shafer NONMEM Workshop with PLT Tools

From: Steven Shafer <steven.shafer>
Date: Fri, 21 May 2010 10:59:56 -0700

Dear Colleagues:


Dennis Fisher and I are pleased to announce the 12th Fisher/Shafer NONMEM
Workshop with PLT Tools, to be held in Bethesda, Maryland from Wednesday,
November 3rd, 2010 through Saturday, November 6th, 2010. You can find the
course description and registration details at


This is an intermediate to advanced course on the use of the NONMEM System,
closely integrated with the PLT Tools graphical user interface for the
NONMEM System. Although the focus of the workshop is NONMEM, the more
advanced diagnostics (e.g., visual predictive check, log-likelihood
profiling, bootstrap analysis, jackknife validation) are presented in the
context of PLT Tools because it automates the generation of these
diagnostics. We introduced automatic covariate searching at the April
workshop in San Francisco, where it was very well received. We also
introduced batch processing of control files and automatic report generation
(in RTF format), frequent requests of NONMEM users in a production
environment, again to very positive user feedback. Automatic covariate
searching, batch processing of NONMEM files, and automatic report generation
will be a standard part of all future courses.


The workshop will be based on NONMEM VI, the standard version of NONMEM for
most users. PLT Tools fully supports NONMEM 7. PLT Tools also supports
NMQUAL, for users who have incorporated NMQUAL into their work environment.


Our NONMEM Workshops are now in their 6th year. Dennis and I have spent the
past four years developing PLT Tools. We introduced PLT Tools in Bethesda,
Maryland in 2009, and have used the biannual workshops to introduce new
features of PLT Tools. The feedback from the three courses since we
introduced PLT Tools (9th, 10th, and 11th) is that workshop participants
appreciated having access to the powerful features of the PLT Tools program.


You can download the fully functional unlicensed version of PLT Tools from


Participants are encouraged to consider two introductory courses:

  . Introduction to R: The day before the workshop (Tuesday, November 2nd),
we teach two half-day courses: "Data Manipulation" (Tuesday morning) and
"Statistics and Graphics (Tuesday afternoon).

  . Introduction to NONMEM: Participants who would like to brush up on
NONMEM before starting the workshop on Wednesday are encouraged to attend
this half-day session (Tuesday afternoon).


Participants interested in additional training in PLT Tools can sign up for
a half-day course devoted to PLT Tools we give on the afternoon of the last
day (Saturday, November 6th). The course covers PLT Tools in far greater
detail, focusing on a series of examples in which PLT Tools handles types of
data analysis that are unwieldy if one attempts to work directly with


Dennis and I hope to see you in November in Bethesda!




Steven L. Shafer, MD

Professor of Anesthesiology, Columbia University

Adjunct Professor of Anesthesia, Stanford University

Adjunct Professor of Biopharmaceutical Sciences, UCSF

Editor-in-Chief, Anesthesia & Analgesia


Received on Fri May 21 2010 - 13:59:56 EDT

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