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Modeling & Simulation Scientist (Nonclinical DMPK)

From: christopher.kohl
Date: Tue, 25 May 2010 11:00:31 +0200

Modeling & Simulation Scientist (Nonclinical DMPK)
About the Company
Actelion (www.actelion.com) is a biopharmaceutical company founded in
1997, headquartered in Allschwil/Basel, Switzerland. Today with about
2?000 people in 28 countries we
focus on discovery, development and marketing of original, innovative
drugs for highly unmet medical needs. Our successfully marketed compounds=
 
are
Tracleer® and Ventavis® for the treatment of pulmonary arterial
hypertension and Zavesca®, the only approved oral treatment for Gaucher=
 
disease. Actelion
shares are traded as part of the blue-chip SMI® (Swiss Market Index) sinc=
e
2008. Actelion combines the innovation, entrepreneurial spirit and
flexibility of biotech
with the financial, risk management, regulatory and commercial discipline=
 
of a large pharmaceutical company. We have ambitious plans to keep
improving and
growing ? and are looking for people as innovative as ourselves.
Job Responsibilities
Providing quantitative pharmacokinetic and pharmacodynamic modelling and
simulation expertise to pre-clinical project and Life cycle teams
Applying quantitative PK/PD modelling and simulation to inform
pre-clinical candidate selection
Being a champion and advocate for pharmacometrics within the company
Analyzing, interpreting and reporting pharmacokinetic and pharmacodynamic=
 
data from pre-clinical studies
Performing PK/PD simulations and predicting pre-clinical and clinical PK
from nonclinical data as appropriate
Collaborating, mentoring and guiding other DMPK team members with
pharmacometric support on their projects
Interacting cross-functionally with other departments including Medical
Organization, Toxicology, Formulation and Discovery
Preparing and/or reviewing PK, PK/PD components of internal documents,
briefing books and regulatory submission documents (e.g. IND, NDA, IB and
other regulatory documents)
Actively preparing, reviewing and publishing scientific papers and
abstracts
Representing the DMPK line on project teams
Candidate Requirements
PhD in relevant discipline (e.g. Quantitative Pharmacology, Pharmaceutical=
 
Sciences, Chemical Engineering)
2 to 3 years experience in Modelling and Simulation in the Pharmaceutical=
 
Industry or Contract Research Organisations
Proficient in spoken and written English
Strong understanding of pharmacokinetic and pharmacodynamic principles
including PBPK
Hands-on experience with modelling and simulation software packages
(WinNonlin Phoenix, NonMEM, R, Splus)
Experience with Gastroplus, SimCYP would be advantageous
Must be a team player and great communicator.
What Actelion Offers
A competitive salary and generous social benefits
The possibility for development and advancement within a constantly
growing company
The innovative and stimulating atmosphere of a multicultural environment

The research facilities are located in Allschwil, Switzerland, a suburb of=
 
Basel close to the borders of France and Germany.



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e them to be the views of the sender's company. For further information abo=
ut Actelion please see our website at http://www.actelion.com



Received on Tue May 25 2010 - 05:00:31 EDT

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