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Re: Inclusion of Analytical Expressions in NONMEM control file

From: Nick Holford <n.holford>
Date: Fri, 04 Feb 2011 07:39:03 +1300

Georgios,

Leonid has already asked you to make it clearer what you are trying to do.

Coding "analytical expressions" that do not involve $DES or other PREDPP
subroutines in NONMEM may be done using $PRED e.g.

$INPUT ID DOSE DV
$THETA 1
$OMEGA 1
$SIGMA 1
$PRED
D50=THETA(1)*EXP(ETA(1)
Y=DOSE/(DOSE+D50) + EPS(1)

This estimates the D50 for a dose-response relationship with an
exponential random effects model for D50 and an additive random effect
for the residual error. The dose response is assumed to have a maximum
of 1 in this very simple example.

Nick

On 4/02/2011 6:49 a.m., Leonid Gibiansky wrote:
> Addition:
>
> I assumed that you need to use analytical equations; if you need just
> expressions, you can do it in the error block like
>
> TEMP=A(1)/V1
> Y=(TEMP**2+1)**0.5 + EPS(1)
>
> If you need something else, please, give an example of what exactly
> you are trying to implement
> Regards,
> Leonid
>
>
> On 2/3/2011 12:39 PM, Leonid Gibiansky wrote:
>> you can use ADNVAN9 $AES (see manual) although it is much better
>> (quicker and more stable) to solve them (if possible) analytically.
>> Leonid
>>
>> --------------------------------------
>> Leonid Gibiansky, Ph.D.
>> President, QuantPharm LLC
>> web: www.quantpharm.com
>> e-mail: LGibiansky at quantpharm.com
>> tel: (301) 767 5566
>>
>>
>>
>> On 2/3/2011 11:50 AM, Georgios Vlasakakis wrote:
>>> Dear NONMEM users
>>>
>>> Has anyone ever tried to include analytical expressions within a
>>> control
>>> file in NOMEM? I guess that would obviously imply the use of a routine
>>> alternative to the $DES.
>>>
>>> Id appreciate if you could provide me with some tips or a short
>>> example
>>> on that.
>>>
>>> Many thanks in advance,
>>>
>>> Georgios
>>>
>>> /Georgios Vlasakakis, BEng///
>>>
>>> Post-Doctoral Fellow
>>>
>>> GlaxoSmithKline, Middlesex, UB11 1BT, Stockley Park
>>>
>>> CPMS Development and Technologies
>>> <https://connect.gsk.com/sites/cpms/TandD/Pages/default.aspx>
>>>
>>> Quantitative Sciences, R&D
>>>
>>> Internal Phone Number: 792 2047
>>>
>>> External: +44 (0) 208 990 2047
>>>
>>> email: georgios.x.vlasakakis
>>>

--
Nick Holford, Professor Clinical Pharmacology
Dept Pharmacology& Clinical Pharmacology
University of Auckland,85 Park Rd,Private Bag 92019,Auckland,New Zealand
tel:+64(9)923-6730 fax:+64(9)373-7090 mobile:+64(21)46 23 53
email:n.holford
http://www.fmhs.auckland.ac.nz/sms/pharmacology/holford


Received on Thu Feb 03 2011 - 13:39:03 EST

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