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RE: Inclusion of Analytical Expressions in NONMEM control file

From: Georgios Vlasakakis <georgios.x.vlasakakis>
Date: Fri, 4 Feb 2011 14:49:54 +0100


Dear all

Many thanks for your feedback and apologies for my late reply.

Maybe my first message wasn't clear enough but I'm interested in "bypassing=
" the existing libraries in PREDPP in order to include the model's analytic=
al solution instead of an ADVAN or set of differential equations ($DES).
I think I got the solution through Leonid's & Nick's replies. Thank you all=
 for your valuable feedback.

Best
Georgios




From: owner-nmusers
 Behalf Of Nick Holford
Sent: 03 February 2011 18:39
To: nmusers
Subject: Re: [NMusers] Inclusion of Analytical Expressions in NONMEM contro=
l file

Georgios,

Leonid has already asked you to make it clearer what you are trying to do.

Coding "analytical expressions" that do not involve $DES or other PREDPP su=
broutines in NONMEM may be done using $PRED e.g.

$INPUT ID DOSE DV
$THETA 1
$OMEGA 1
$SIGMA 1
$PRED
D50=THETA(1)*EXP(ETA(1)
Y=DOSE/(DOSE+D50) + EPS(1)

This estimates the D50 for a dose-response relationship with an exponential=
 random effects model for D50 and an additive random effect for the residua=
l error. The dose response is assumed to have a maximum of 1 in this very s=
imple example.

Nick

On 4/02/2011 6:49 a.m., Leonid Gibiansky wrote:
Addition:

I assumed that you need to use analytical equations; if you need just expre=
ssions, you can do it in the error block like

TEMP=A(1)/V1
Y=(TEMP**2+1)**0.5 + EPS(1)

If you need something else, please, give an example of what exactly you are=
 trying to implement
Regards,
Leonid


On 2/3/2011 12:39 PM, Leonid Gibiansky wrote:

you can use ADNVAN9 $AES (see manual) although it is much better
(quicker and more stable) to solve them (if possible) analytically.
Leonid

--------------------------------------
Leonid Gibiansky, Ph.D.
President, QuantPharm LLC
web: www.quantpharm.com<http://www.quantpharm.com>
e-mail: LGibiansky at quantpharm.com
tel: (301) 767 5566



On 2/3/2011 11:50 AM, Georgios Vlasakakis wrote:

Dear NONMEM users

Has anyone ever tried to include analytical expressions within a control
file in NOMEM? I guess that would obviously imply the use of a routine
alternative to the $DES.

I'd appreciate if you could provide me with some tips or a short example
on that.

Many thanks in advance,

Georgios

/Georgios Vlasakakis, BEng///

Post-Doctoral Fellow

GlaxoSmithKline, Middlesex, UB11 1BT, Stockley Park

CPMS Development and Technologies
<https://connect.gsk.com/sites/cpms/TandD/Pages/default.aspx><https://conne=
ct.gsk.com/sites/cpms/TandD/Pages/default.aspx>

Quantitative Sciences, R&D

Internal Phone Number: 792 2047

External: +44 (0) 208 990 2047

email: georgios.x.vlasakakis



--

Nick Holford, Professor Clinical Pharmacology

Dept Pharmacology & Clinical Pharmacology

University of Auckland,85 Park Rd,Private Bag 92019,Auckland,New Zealand

tel:+64(9)923-6730 fax:+64(9)373-7090 mobile:+64(21)46 23 53

email: n.holford

http://www.fmhs.auckland.ac.nz/sms/pharmacology/holford

Received on Fri Feb 04 2011 - 08:49:54 EST

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