NONMEM Users Network Archive

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lagged absorption and empirical input function

From: Tremblay, Pierre-Olivier <potremblay>
Date: Wed, 27 Jul 2011 17:10:04 -0400


I'm trying to implement an absorption lag-time into a model described by =
differential equations and using an empirical input function.

My initial idea was to define a MTIME(1) corresponding to the lag-time =
and to use MPAST(1) to set the start of the input as below.


However, I only end up with no input at all in the system resulting in =
simulated DV of 0 residual error. The issue seems related to the =
use MPAST with the input function but I don't know how.

Would anyone be kind enough to point me in the right direction?



Received on Wed Jul 27 2011 - 17:10:04 EDT

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