NONMEM Users Network Archive

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RE: NM7.2 SAEM with LIKE

From: Bauer, Robert <Robert.Bauer>
Date: Tue, 7 Aug 2012 16:28:21 +0000

Filip:
The $TABLE results are obtained from a "post-hoc" assessment at the best fi=
t eta values (modal, EBE), regardless of the method used. To evaluate $TAB=
LE parameters at the conditional mean positions, you may select FNLETA=0.

Robert J. Bauer, Ph.D.
Vice President, Pharmacometrics, R&D
ICON Development Solutions
7740 Milestone Parkway
Suite 150
Hanover, MD 21076
Tel: (215) 616-6428
Mob: (925) 286-0769
Email: Robert.Bauer
Web: www.iconplc.com<http://www.iconplc.com/>


________________________________
From: owner-nmusers
 Behalf Of De Ridder, Filip [JRDBE]
Sent: Tuesday, August 07, 2012 10:18 AM
To: nmusers
Subject: [NMusers] NM7.2 SAEM with LIKE

Dear All,

With NM7.2/SAEM, the root.phi output file contains the conditional means (a=
nd variances) of the individual phi's (mu(i)+eta(i)) - which is great! I =
found that the these values can be different from what you get from a $TABL=
E in more classical way:

$PRED
MU_1=THETA(1)
K=MU_1+ETA(1)
...
$TABLE K ...

For a some subjects, these are very different, and the ones coming from the=
 $TABLE are clearly less optimal, yielding a bad individual fit, as judged =
from IPRE calculated in $PRED.

I guess one part of the solution is using CPRED and CPREDI - but unfortuna=
tely I cannot use these as I (have to) use LIKELIHOOD in $EST (M3 method f=
or BLQ-data).


Kind regards,

Filip De Ridder
Janssen R&D, Beerse, Belgium.



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Received on Tue Aug 07 2012 - 12:28:21 EDT

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