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Mixture model

From: Fisher Dennis <fisher>
Date: Thu, 12 Jul 2012 13:25:17 -0700

Colleagues

I am analyzing data in which there are two distinct populations as a =
result of CYP2D6 deficiency. In one dataset, there are 18 subjects with =
rich data; one of these subjects is markedly different. In that the =
incidence of 2D6 deficiency is reported to be < 10%, one would expect =
only 1-2 deficient subjects in this sample (consistent with the data =
here).

I was planning to use a mixture model as part of the analysis. However, =
with only one subject in the deficient population, I am not sure if that =
is appropriate.

Does anyone have any relevant experience or insight into this issue?

Dennis

Dennis Fisher MD
P < (The "P Less Than" Company)
Phone: 1-866-PLessThan (1-866-753-7784)
Fax: 1-866-PLessThan (1-866-753-7784)
www.PLessThan.com


Received on Thu Jul 12 2012 - 16:25:17 EDT

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